| Resting and exercise cardiorespiratory function in survivors of congenital diaphragmatic hernia. | |
| | |
MedLine Citation:
|
PMID: 16617447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Our objective was to study exercise capacity and cardiorespiratory response to exertion in survivors of congenital diaphragmatic hernia (CDH). This was a cross-sectional cohort study of 23 CDH survivors, aged 10-16 years, and 23 gender- and age-matched controls. Exercise testing was performed on a cycle ergometer, with cardiac output measurements made using exponential CO2 rebreathing. Pretest cardiorespiratory assessment was done by echocardiography and pulmonary function testing. Statistical analysis was performed using Student's t-test, regression analysis, and longitudinal model computing with spatial covariance structure. No echocardiographic evidence for pulmonary hypertension was found at rest (right ventricular systolic pressures, 27 +/- 6 mmHg). Mean pulmonary artery diameter on the side of the CDH was significantly smaller than contralaterally, but was within normal range (z-score, 0 +/- 1.1 vs. 1.2 +/- 1.6, P < 0.01). Exercise capacity was mildly reduced in CDH compared to controls and predictive data (maximum workload, 77% +/- 12% vs. 91% +/- 16% of predicted, P < 0.01). Cardiorespiratory response to exertion was not significantly different between groups. In conclusion, most adolescent CDH survivors have nearly normal exercise capacity and cardiorespiratory response to exertion. This study may prove useful in comparisons with future cohorts comprising more severely affected individuals now surviving due to improved neonatal care. |
| | |
Authors:
|
Daniel Trachsel; Hiran Selvadurai; Ian Adatia; Desmond Bohn; Jane Schneiderman-Walker; Donna Wilkes; Allan L Coates |
Related Documents
:
|
7555167 - Short-term effects of postural drainage with clapping vs autogenic drainage on oxygen s... 7457397 - Hemodynamics at rest and during exercise after oral hydralazine in patients with cor pu... 20085827 - Dynamic vs. fixed bag filling: impact on cardiac output rebreathing protocol. 1554207 - Recruitment of diffusing capacity with exercise in patients after pneumonectomy. 1884697 - Clinical evaluation of poor performance in the racehorse: the results of 275 evaluations. 16893447 - Exposure of hairdressing apprentices to airborne hazardous substances. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatric pulmonology Volume: 41 ISSN: 8755-6863 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-01 Completed Date: 2006-12-12 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
|
Languages: eng Pagination: 522-9 Citation Subset: IM |
Copyright Information:
|
Copyright 2006 Wiley-Liss, Inc. |
Affiliation:
|
Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Body Weights and Measures Cardiac Output / physiology Cardiovascular Physiological Phenomena* Child Cohort Studies Cross-Sectional Studies Exercise Test Exercise Tolerance / physiology* Female Forced Expiratory Volume / physiology Heart Rate / physiology Hernia, Diaphragmatic / congenital, physiopathology* Humans Lung Volume Measurements Male Oxygen Consumption / physiology Pulmonary Gas Exchange / physiology Residual Volume / physiology Respiratory Function Tests Respiratory Physiological Phenomena* Stroke Volume / physiology Survivors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Airway function measurements and the long-term follow-up of survivors of preterm birth with and with...
Next Document: Airway hyperresponsiveness and body mass index: the Child Health and Environment Cohort Study in Hes...