Document Detail

Resting and exercise cardiorespiratory function in survivors of congenital diaphragmatic hernia.
MedLine Citation:
PMID:  16617447     Owner:  NLM     Status:  MEDLINE    
Our objective was to study exercise capacity and cardiorespiratory response to exertion in survivors of congenital diaphragmatic hernia (CDH). This was a cross-sectional cohort study of 23 CDH survivors, aged 10-16 years, and 23 gender- and age-matched controls. Exercise testing was performed on a cycle ergometer, with cardiac output measurements made using exponential CO2 rebreathing. Pretest cardiorespiratory assessment was done by echocardiography and pulmonary function testing. Statistical analysis was performed using Student's t-test, regression analysis, and longitudinal model computing with spatial covariance structure. No echocardiographic evidence for pulmonary hypertension was found at rest (right ventricular systolic pressures, 27 +/- 6 mmHg). Mean pulmonary artery diameter on the side of the CDH was significantly smaller than contralaterally, but was within normal range (z-score, 0 +/- 1.1 vs. 1.2 +/- 1.6, P < 0.01). Exercise capacity was mildly reduced in CDH compared to controls and predictive data (maximum workload, 77% +/- 12% vs. 91% +/- 16% of predicted, P < 0.01). Cardiorespiratory response to exertion was not significantly different between groups. In conclusion, most adolescent CDH survivors have nearly normal exercise capacity and cardiorespiratory response to exertion. This study may prove useful in comparisons with future cohorts comprising more severely affected individuals now surviving due to improved neonatal care.
Daniel Trachsel; Hiran Selvadurai; Ian Adatia; Desmond Bohn; Jane Schneiderman-Walker; Donna Wilkes; Allan L Coates
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  41     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-01     Completed Date:  2006-12-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  522-9     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Body Weights and Measures
Cardiac Output / physiology
Cardiovascular Physiological Phenomena*
Cohort Studies
Cross-Sectional Studies
Exercise Test
Exercise Tolerance / physiology*
Forced Expiratory Volume / physiology
Heart Rate / physiology
Hernia, Diaphragmatic / congenital,  physiopathology*
Lung Volume Measurements
Oxygen Consumption / physiology
Pulmonary Gas Exchange / physiology
Residual Volume / physiology
Respiratory Function Tests
Respiratory Physiological Phenomena*
Stroke Volume / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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