Document Detail

Resting heart rate as a predictor of body weight gain in the early stage of hypertension.
MedLine Citation:
PMID:  20814417     Owner:  NLM     Status:  MEDLINE    
We did a prospective study to investigate whether clinic heart rate (HR) and 24-h ambulatory HR were independent predictors of subsequent increase in body weight (BW) in young subjects screened for stage 1 hypertension. The study was conducted in 1,008 subjects from the Hypertension and Ambulatory Recording Venetia Study (HARVEST) followed for an average of 7 years. Ambulatory HR was obtained in 701 subjects. Data were adjusted for lifestyle factors and several confounders. During the follow-up BW increased by 2.1 ± 7.2 kg in the whole cohort. Both baseline clinic HR (P = 0.007) and 24-h HR (P = 0.013) were independent predictors of BMI at study end. In addition, changes in HR during the follow-up either measured in the clinic (P = 0.036) or with 24-h recording (P = 0.009) were independent associates of final BMI. In a multivariable Cox regression, baseline BMI (P < 0.001), male gender (P < 0.001), systolic blood pressure (BP) (P = 0.01), baseline clinic HR (P = 0.02), and follow-up changes in clinic HR (P < 0.001) were independent predictors of overweight (Ov) or obesity (Ob) at the end of the follow-up. Follow-up changes in ambulatory HR (P = 0.01) were also independent predictors of Ov or Ob. However, when both clinic and ambulatory HRs were included in the same Cox model, only baseline clinic HR and its change during the follow-up were independent predictors of outcome. In conclusion, baseline clinic HR and HR changes during the follow-up are independent predictors of BW gain in young persons screened for stage 1 hypertension suggesting that sympathetic nervous system activity may play a role in the development of Ob in hypertension.
Paolo Palatini; Lucio Mos; Massimo Santonastaso; Nello Zanatta; Paolo Mormino; Francesca Saladini; Alessandra Bortolazzi; Susanna Cozzio; Guido Garavelli;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-02
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-24     Completed Date:  2011-10-04     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  618-23     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.
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MeSH Terms
Blood Pressure*
Body Mass Index
Heart Rate*
Hypertension / physiopathology*
Obesity / physiopathology*
Proportional Hazards Models
Prospective Studies
Rest / physiology
Sex Factors
Sympathetic Nervous System / physiology*
Weight Gain*
G Catania / ; R Da Cortà / ; G Garavelli / ; F Pegoraro / ; S Laurini / ; D D'Este / ; F Dorigatti / ; F Saladini / ; F Ragazzo / ; A Zanier / ; E Benetti / ; G Cignacco / ; G Zanata / ; M Mattarei / ; T Biasion / ; A Bortolazzi / ; L Mos / ; S Martina / ; O Vriz / ; L Milani / ; C Canali / ; S Cozzio / ; G Calconi / ; P Gatti / ; M Santonastaso / ; N Zanatta / ; R Garbelotto / ; A Mazzer / ; P Palatini /

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