| Resting heart rate and coronary artery calcium in postmenopausal women. | |
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MedLine Citation:
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PMID: 21438696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis of a significant association between resting heart rate (RHR) and coronary artery calcium (CAC). METHODS: This is a cross-sectional study of a subset of women enrolled in the estrogen-alone clinical trial of the Women's Health Initiative (WHI). We used a longitudinal study that enrolled 998 postmenopausal women with a history of hysterectomy between the ages of 50 and 59 at enrollment at 40 different clinical centers. RHR was measured at enrollment and throughout the study, and CAC was determined approximately 7 years after the baseline clinic visit. RESULTS: The mean (standard deviation [SD]) age was 55 (2.8) years. With adjustment for age and ethnicity, a 10-unit increment in RHR was significantly associated with CAC (SD 1.18, 95% confidence interval [CI] 1.01-1.38), but this was no longer significant after adjustment for body mass index (BMI), income, education, dyslipidemia, diabetes, smoking, and hypertension (SD 1.06, 95% CI 0.90-1.25). In a fully adjusted multivariable model, however, there was a significant interaction (p=0.03) between baseline RHR and systolic blood pressure (SBP) for the presence of any CAC. Compared to women with an RHR < 80 beats per minute (BPM) and an SBP < 140 mm Hg, those who had an RHR ≥ 80 BPM and an SBP ≥ 140 mm Hg had 2.66-fold higher odds (1.08-6.57) for the presence of any CAC. CONCLUSIONS: Compared to those with normal BP and RHR, postmenopausal, hysterectomized women with an elevated SBP and RHR have a significantly higher odds for the presence of calcified coronary artery disease. |
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Authors:
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Matthew A Allison; Joann E Manson; Aaron Aragaki; Charles B Eaton; Judith Hsai; Lawrence Phillips; Lewis Kuller; Maurizio Trevisan |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-25 |
Journal Detail:
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Title: Journal of women's health (2002) Volume: 20 ISSN: 1931-843X ISO Abbreviation: J Womens Health (Larchmt) Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-11-15 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 101159262 Medline TA: J Womens Health (Larchmt) Country: United States |
Other Details:
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Languages: eng Pagination: 661-9 Citation Subset: IM |
Affiliation:
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University of California San Diego, La Jolla, California 92093-0965, USA. mallison@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcinosis
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complications*,
epidemiology* Calcium / blood, metabolism* Clinical Trials as Topic Coronary Artery Disease / blood, complications*, epidemiology Coronary Vessels / metabolism* Cross-Sectional Studies Female Heart Rate / physiology* Humans Hypertension / complications, epidemiology Hysterectomy Longitudinal Studies Middle Aged Multivariate Analysis Postmenopause Randomized Controlled Trials as Topic Rest Risk Factors Smoking / adverse effects, epidemiology United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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N01WH22110/WH/WHI NIH HHS; N01WH24152/WH/WHI NIH HHS; N01WH32100/WH/WHI NIH HHS; N01WH32101/WH/WHI NIH HHS; N01WH32102/WH/WHI NIH HHS; N01WH32105/WH/WHI NIH HHS; N01WH32106/WH/WHI NIH HHS; N01WH32108/WH/WHI NIH HHS; N01WH32109/WH/WHI NIH HHS; N01WH32111/WH/WHI NIH HHS; N01WH32112/WH/WHI NIH HHS; N01WH32113/WH/WHI NIH HHS; N01WH32115/WH/WHI NIH HHS; N01WH32118/WH/WHI NIH HHS; N01WH32119/WH/WHI NIH HHS; N01WH32122/WH/WHI NIH HHS; N01WH42107/WH/WHI NIH HHS; N01WH42108/WH/WHI NIH HHS; N01WH42109/WH/WHI NIH HHS; N01WH42110/WH/WHI NIH HHS; N01WH42111/WH/WHI NIH HHS; N01WH42112/WH/WHI NIH HHS; N01WH42113/WH/WHI NIH HHS; N01WH42114/WH/WHI NIH HHS; N01WH42115/WH/WHI NIH HHS; N01WH42116/WH/WHI NIH HHS; N01WH42117/WH/WHI NIH HHS; N01WH42118/WH/WHI NIH HHS; N01WH42119/WH/WHI NIH HHS; N01WH42120/WH/WHI NIH HHS; N01WH42121/WH/WHI NIH HHS; N01WH42122/WH/WHI NIH HHS; N01WH42123/WH/WHI NIH HHS; N01WH42124/WH/WHI NIH HHS; N01WH42125/WH/WHI NIH HHS; N01WH42126/WH/WHI NIH HHS; N01WH42129/WH/WHI NIH HHS; N01WH42130/WH/WHI NIH HHS; N01WH42131/WH/WHI NIH HHS; N01WH42132/WH/WHI NIH HHS; N01WH44221/WH/WHI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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