|Resting energy expenditure at 3 months of age following neonatal surgery for congenital heart disease.|
|PMID: 23360096 Owner: NLM Status: MEDLINE|
|OBJECTIVE: Infants with Congenital Heart Disease (CHD) often exhibit growth failure. This can affect anthropometric and neurodevelopmental outcomes well into childhood. To determine the resting energy expenditure (REE), body composition, and growth in infants with CHD at 3 months of age, with the secondary aim to identify predictors of REE as compared with healthy infants.
DESIGN AND METHODS: This descriptive study is a subanalysis of a prospective study investigating predictors of growth in postoperative infants with CHD compared with healthy infants. Growth measurements, REE, and body composition were obtained in all infants. Analysis included chi-square for association between categorical variables, t-tests, ANOVA and ANCOVA. Outcome measures included the REE as determined by indirect calorimetry, anthropometric z-scores and body composition at 3 months of age.
SETTING: Participants were recruited from the Cardiac Intensive Care Unit of a large, urban, pediatric cardiac center and pediatric primary care practices.
RESULTS: The analysis included 93 infants, 44 (47%) with CHD. Of the infants with CHD, 39% had single ventricle (SV) physiology. There was no difference in REE related to cardiac physiology between infants with CHD and healthy infants or between infants with SV and biventricular (BV) physiology. Anthropometric z-scores for weight (-1.1 ± 1.1, P < 0.001), length (-0.7 ± 1.1, P < 0.05), and head circumference (-0.6 ± 1.2, P < 0.001) were lower in infants with CHD at 3 months of age. The percentage of body fat (%FAT) in postoperative infants with SV (24% ± 6, P = 0.02) and BV (23% ± 5, P < 0.001) physiology were lower than in healthy infants (27% ± 5), with no difference in REE.
CONCLUSION: At 3 months of age, there was no difference in REE between postsurgical infants with CHD and healthy infants. Infants with CHD had lower growth z-scores and %FAT. These data demonstrate decreased %FAT contributed to growth failure in the infants with CHD.
|Sharon Y Irving; Barbara Medoff-Cooper; Nicole O Stouffer; Joan I Schall; Chitra Ravishankar; Charlene W Compher; Bradley S Marino; Virginia A Stallings|
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|Type: Journal Article Date: 2013-01-30|
|Title: Congenital heart disease Volume: 8 ISSN: 1747-0803 ISO Abbreviation: Congenit Heart Dis Publication Date: 2013 Jul-Aug|
|Created Date: 2013-07-23 Completed Date: 2014-02-26 Revised Date: 2014-07-02|
Medline Journal Info:
|Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States|
|Languages: eng Pagination: 343-51 Citation Subset: IM|
|© 2013 Wiley Periodicals, Inc.|
|APA/MLA Format Download EndNote Download BibTex|
Analysis of Variance
Cardiac Surgical Procedures* / adverse effects
Growth Disorders / etiology, metabolism, physiopathology
Head / growth & development
Heart Defects, Congenital / metabolism, surgery*
Primary Health Care
|M01 RR000240/RR/NCRR NIH HHS|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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