| Resting brain connectivity: changes during the progress of Alzheimer disease. | |
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MedLine Citation:
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PMID: 20656843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate alterations in functional connectivity in the resting brain networks in healthy elderly volunteers and patients with mild, moderate, or severe Alzheimer Disease (AD). MATERIALS AND METHODS: This study was approved by the institutional ethics committee, and informed consent was obtained. Forty-six patients with AD and 16 healthy elderly volunteers were prospectively examined. Resting-state functional magnetic resonance imaging was used to detect alterations in posterior cingulate cortex (PCC) functional connectivity through a comparison of the healthy control group with three separate AD groups-mild, moderate, and severe AD. A temporal correlation method was used to obtain PCC connectivity maps. RESULTS: Dissociated functional connectivity between the PCC and a set of regions, including the visual cortices bilaterally, the inferior temporal cortex, the hippocampus, and especially the medial prefrontal cortex and the precuneus and/or cuneus, was observed in all AD groups. The disruption of connectivity intensified as the stage of AD progression increased. There were also regions that exhibited increased connectivity; these regions extended from left lateralized frontoparietal regions and spread to bilateral frontoparietal regions along with AD progression. CONCLUSION: Changes in PCC functional connectivity comprised bidirectional alterations in the resting networks in AD-affected brains, and the impaired resting functional connectivity seemed to change with AD progression. Therefore, alterations in functional connectivity in the default mode network might play a role in the progression of AD. |
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Authors:
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Hong-Ying Zhang; Shi-Jie Wang; Bin Liu; Zhan-Long Ma; Ming Yang; Zhi-Jun Zhang; Gao-Jun Teng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 256 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 598-606 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Jiangsu Key Laboratory of Molecule Imaging and Functional Imaging, Medical School of Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis, physiopathology* Brain / physiopathology* Female Humans Magnetic Resonance Imaging / methods* Male Middle Aged Nerve Net / physiopathology* Neural Pathways / physiopathology* |
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