Document Detail

Restenosis following implantation of bare metal coronary stents: pathophysiology and pathways involved in the vascular response to injury.
MedLine Citation:
PMID:  16733073     Owner:  NLM     Status:  MEDLINE    
This review summarizes the restenotic process that occurs after the implantation of bare metal coronary stents. The pathology of in-stent restenosis is distinct from that seen after balloon angioplasty and is characterized by neointimal proliferation and extracellular matrix deposition. The degree of neointimal proliferation is proportional to the amount of injury, the intensity of the inflammatory infiltrate and the association of stent struts with lipid-filled plaque. In-stent restenosis also appears to be associated with systemic markers of inflammation. Shear stress has an important influence on restenosis as does the presence and adhesiveness of vascular progenitor cells. Clinical predictors (e.g., artery size, stent length, diabetes, and gender) may affect the incidence of restenosis seen after stent placement. A number of catheter-based interventions have been used to treat in-stent restenosis. Although preliminary data suggest that the use of drug-eluting stents may be effective, only intracoronary radiation has shown consistent efficacy in randomized trials.
Neal A Scott
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Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2006-03-06
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  58     ISSN:  0169-409X     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-08     Completed Date:  2006-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  358-76     Citation Subset:  IM    
Camino Cardiovascular Associates, 525 South Drive, Suite 107, Mountain View, CA 94040, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Coated Materials, Biocompatible / chemistry,  therapeutic use
Coronary Restenosis / etiology,  physiopathology,  therapy*
Extracellular Matrix / metabolism
Inflammation / metabolism,  physiopathology
Postoperative Complications / physiopathology
Stents / adverse effects*
Tunica Intima / injuries,  physiopathology*
Reg. No./Substance:
0/Coated Materials, Biocompatible

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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