| Rest in Drosophila is a sleep-like state. | |
| | |
MedLine Citation:
|
PMID: 10707978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To facilitate the genetic study of sleep, we documented that rest behavior in Drosophila melanogaster is a sleep-like state. The animals choose a preferred location, become immobile for periods of up to 157 min at a particular time in the circadian day, and are relatively unresponsive to sensory stimuli. Rest is affected by both homeostatic and circadian influences: when rest is prevented, the flies increasingly tend to rest despite stimulation and then exhibit a rest rebound. Drugs acting on a mammalian adenosine receptor alter rest as they do sleep, suggesting conserved neural mechanisms. Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep. |
| | |
Authors:
|
J C Hendricks; S M Finn; K A Panckeri; J Chavkin; J A Williams; A Sehgal; A I Pack |
Related Documents
:
|
18985738 - Ocular coloboma and dorsoventral neuroretinal patterning defects in lrp6 mutant eyes. 1219058 - Genetics of eye-gap and maroon-eye mutants in the mosquito. 12163408 - Six3 inactivation reveals its essential role for the formation and patterning of the ve... 7910468 - The drosophila sine oculis locus encodes a homeodomain-containing protein required for ... 9771168 - Surgical face masks and downward dispersal of bacteria. 21530088 - Solitary sleeping in young infants is associated with heightened cortisol reactivity to... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neuron Volume: 25 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2000 Jan |
Date Detail:
|
Created Date: 2000-03-23 Completed Date: 2000-03-23 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 8809320 Medline TA: Neuron Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 129-38 Citation Subset: IM |
Affiliation:
|
Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA. jch@vet.upeen.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Genetically Modified Circadian Rhythm / physiology Drosophila Proteins* Drosophila melanogaster / physiology* Gene Expression / physiology Insect Proteins / genetics*, metabolism Male Mutagenesis / physiology Nervous System / cytology Neurons, Afferent / physiology Nuclear Proteins / genetics*, metabolism Period Circadian Proteins Rest / physiology* Sleep / genetics* Sleep Deprivation |
| Grant Support | |
ID/Acronym/Agency:
|
HL 60287/HL/NHLBI NIH HHS; R01 HL 59496/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Drosophila Proteins; 0/Insect Proteins; 0/Nuclear Proteins; 0/PER protein, Drosophila; 0/Period Circadian Proteins; 0/timeless protein, Drosophila |
| Comments/Corrections | |
Comment In:
|
Neuron. 2000 May;26(2):295-8
[PMID:
10839349
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GABA synchronizes clock cells within the suprachiasmatic circadian clock.
Next Document: The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+...