Document Detail


Rest and exercise performance of the Medtronic Advantage bileaflet valve in the aortic position.
MedLine Citation:
PMID:  16181862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of the study was to evaluate rest and exercise performance and left ventricular mass regression of the Medtronic Advantage (Medtronic, Inc, Minneapolis, MN) prosthesis in the aortic position at 1 year at a single center as part of a multicenter, prospective clinical trial. METHODS: Between May 2002 and June 2003, 63 consecutive patients underwent aortic valve replacement with a Medtronic Advantage prosthesis (84.1% male; mean age, 56.0 +/- 9.7 years; ejection fraction, 56.5 +/- 15.8%). Valve lesions were stenosis (n = 20), mixed (n = 34), and insufficiency (n = 9). Concomitant procedures were performed in 34.9%. Follow-up was 100% complete. Echocardiographic data were obtained early postoperatively and at 1 year, combined with stress echocardiography by treadmill. Mean pressure gradients, stroke volume, and left ventricular mass were determined by echocardiography. Data are presented as mean +/- standard deviation. RESULTS: Operative mortality was 0%. Valve-related complications were observed in 2 patients (endocarditis, n = 1; thromboembolic event, n = 1). There was no case of antithromboembolic hemorrhage, prosthesis-related explant, or reoperation. One patient showed moderate paravalvular regurgitation. Mean pressure gradients 1 year postoperatively ranged from 6.3 to 11.0 mm Hg across all valve sizes. Left ventricular mass regression at 1 year was 18.4% across all valve sizes (p < 0.001). No severe patient-prosthesis mismatch (effective orifice area index < or = 0.65 cm2/m2) could be observed. CONCLUSIONS: After 1 year, the Medtronic Advantage valve shows comparable transvalvular mean pressure gradients across the valve sizes used during rest and exercise. This is accompanied by a significant left ventricular mass regression, an important indicator for long-term survival.
Authors:
Ralf Guenzinger; Walter B Eichinger; Florian Botzenhardt; Sabine Bleiziffer; Ina Wagner; Robert Bauernschmitt; Stephen M Wildhirt; Ruediger Lange
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  80     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2006-09-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1319-26     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiothoracic Surgery, German Heart Center Munich, Technical University of Munich, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aortic Valve*
Aortic Valve Insufficiency / physiopathology,  surgery*
Exercise
Female
Follow-Up Studies
Heart Valve Prosthesis*
Heart Valve Prosthesis Implantation / methods
Heart Ventricles / pathology,  ultrasonography
Hemodynamics
Humans
Male
Middle Aged
Organ Size
Prosthesis Design
Rest
Survival Analysis
Treatment Outcome
Comments/Corrections
Comment In:
Ann Thorac Surg. 2005 Oct;80(4):1326   [PMID:  16181863 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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