Document Detail

Responsiveness and variability of airflow obstruction in chronic obstructive pulmonary disease. Clinicopathologic correlative studies.
MedLine Citation:
PMID:  7881649     Owner:  NLM     Status:  MEDLINE    
We have studied the relationships between pulmonary lesions and bronchodilator response and variability of FEV1 in 41 patients enrolled in the National Institutes of Health Intermittent Positive Pressure Breathing Trial who died, came to autopsy, and provided adequate tissue to quantitate lesions. The patients had moderate to severe chronic airflow obstruction and various degrees of response to 250 micrograms isoproterenol inhalation. Airway responsiveness was positively correlated with bronchial eosinophilia, bronchial inflammation, and bronchiolar fibrosis, and it was negatively correlated with bronchiolar goblet cell metaplasia and emphysema. Patients with an increase of 190 ml or more in FEV1 after bronchodilator had less bronchial cartilage and less goblet metaplasia in bronchioles. Airway smooth muscle was not related to airway responsiveness and variability. Flow rates were adversely affected by bronchial eosinophilia for given emphysema scores. This study shows the importance of the eosinophil as part of chronic nonspecific lung disease. Lack of airway responsiveness was associated with lesions such as emphysema and goblet cell metaplasia, which by themselves cause severe chronic airflow obstruction. The better-preserved lung function in patients with increased airway responsiveness is attributed to negative correlations with emphysema and positive correlations with bronchial eosinophilia.
A Nagai; W M Thurlbeck; K Konno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  151     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-07     Completed Date:  1995-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  635-9     Citation Subset:  AIM; IM    
First Department of Medicine, Tokyo Women's Medical College, Japan.
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MeSH Terms
Bronchi / pathology*,  physiopathology*
Bronchoconstriction / drug effects
Forced Expiratory Volume
Isoproterenol / pharmacology
Metaplasia / pathology
Middle Aged
Muscle, Smooth / pathology,  physiopathology
Pulmonary Emphysema / pathology*,  physiopathology*
Pulmonary Eosinophilia / pathology,  physiopathology
Reg. No./Substance:

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