| Responsiveness of the rabbit eye to adrenergic and cholinergic agonists after treatment with 6-hydroxydopamine or alpha-methyl-para-tyrosine: part II--intraocular pressure changes. | |
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MedLine Citation:
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PMID: 32824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of adrenergic and cholinergic drugs on intraocular pressure after chemical sympathectomy produced by 6-hydroxydopamine has been examined in rabbits. For comparison, ocular tension in response to these same drugs has been measured after chronic treatment of rabbits with the norepinephrine synthesis inhibitor alpha-methyl-para-tyrosine. The results indicated that the effects of these 2 treatments were both qualitatively and quantitatively similar. In both cases, supersensitivity to the pressure-lowering effects of alpha and beta adrenergic amines developed. After administration of cholinergic drugs, however, ocular tension became elevated to values ranging from 3 to 7 mm Hg above the baseline levels. |
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Authors:
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B K Colasanti; R R Trotter |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of ophthalmology Volume: 10 ISSN: 0003-4886 ISO Abbreviation: Ann Ophthalmol Publication Date: 1978 Sep |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0210137 Medline TA: Ann Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1209-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Agonists* Animals Carbachol / pharmacology Echothiophate Iodide / pharmacology Epinephrine / pharmacology Hydroxydopamines / pharmacology* Intraocular Pressure / drug effects* Isoproterenol / pharmacology Male Methyltyrosines / pharmacology* Norepinephrine / pharmacology Parasympathomimetics / pharmacology* Rabbits Sympathetic Nervous System / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agonists; 0/Hydroxydopamines; 0/Methyltyrosines; 0/Parasympathomimetics; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-83-2/Carbachol; 513-10-0/Echothiophate Iodide; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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