Document Detail

Responsiveness of intrinsic cardiac neurons to left atrial and hypothalamic cardioactive peptides.
MedLine Citation:
PMID:  11570699     Owner:  NLM     Status:  MEDLINE    
This study was designed to investigate whether cardioactive peptides derived from left atrial tissue or the hypothalamus modulate neurons within the intrinsic cardiac nervous system. Peptides derived from left atrial or left auricular tissues with known coronary artery dilator properties were administered (0.1 ml; 100 microM dose) individually over 10-s periods into the arterial blood supply of ventral ventricular neurons in 11 anesthetized pigs (19-28 kg). Similarly, three hypothalamic protein-hormonal complexes that express coronary artery vasodilator properties, protein-hormone complexes C, G and K, were studied. Each peptide modified the activity generated by some of the neurons identified in a locus of the ventral ventricular ganglionated plexus of each animal. The hypothalamic peptides elicited primarily excitatory responses, whereas the atrial ones induced more suppressor than excitatory responses. Cardiovascular indices remained unchanged overall, indicating that observed neuronal effects were not secondary to cardiodynamic alterations. These data indicate that intrinsic cardiac neurons are sensitive to left atrial and hypothalamic peptides that exhibit coronary artery dilator properties.
A Galoyan; R Srapionian; R C Arora; J A Armour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  92     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-25     Completed Date:  2002-02-19     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM    
H. Burniatian Institute of Biochemistry, National Academy of Sciences of the Republic of Armenia, Yerevan.
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MeSH Terms
Action Potentials / drug effects
Autonomic Nervous System / cytology*
Electrocardiography / drug effects
GTP-Binding Proteins / metabolism
Heart / innervation*
Heart Atria / chemistry,  innervation
Heart Ventricles / innervation
Hypothalamus / chemistry
Myocardium / chemistry
Neurons / drug effects*
Neuropeptides / isolation & purification,  pharmacology*
Ventricular Pressure / drug effects
Reg. No./Substance:
0/Neuropeptides; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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