Document Detail

Responsiveness and habituation of soluble ICAM-1 to acute psychosocial stress in men: determinants and effect of stress-hemoconcentration.
MedLine Citation:
PMID:  17184150     Owner:  NLM     Status:  MEDLINE    
We studied the psychophysiology of soluble intercellular adhesion molecule-1 (sICAM-1) in 25 apparently healthy middle-aged men who underwent an acute psychosocial stressor three times with one week apart. Measures of the biological stress response were obtained at week one and three. The magnitude of the sICAM-1 stress response showed no habituation between individual visits. At week one, cognitive stress appraisal independently predicted integrated sICAM-1 area under the curve (AUC) between rest, immediately post-stress, and 45 min and 105 min post-stress (beta=0.67, p=0.012, deltaR(2)=0.41). Diastolic blood pressure AUC (beta=-0.45, p=0.048, deltaR(2)=0.21) and heart rate AUC (beta=0.44, p=0.055, deltaR(2)=0.21) were independent predictors of sICAM-1 AUC at week three. Adjustment for hemoconcentration yielded a decrease in sICAM-1 levels from rest to post-stress (p<0.001). Stress responsiveness of plasma sICAM-1 was predicted by stress perception and hemodynamic reactivity and affected by stress-hemoconcentration but unrelated to cortisol reactivity and not readily adapting to repeated stress.
R von Känel; D Preckel; B M Kudielka; J E Fischer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-19
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  56     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-01     Completed Date:  2008-02-14     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  627-39     Citation Subset:  IM    
Department of General Internal Medicine, University Hospital/Inselspital, Bern, Switzerland.
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MeSH Terms
Acute Disease
Adaptation, Psychological*
Area Under Curve
Blood Pressure
Case-Control Studies
Habituation, Psychophysiologic*
Heart Rate
Hydrocortisone / blood
Intercellular Adhesion Molecule-1 / blood*
Middle Aged
Stress, Psychological / blood*,  physiopathology
Time Factors
Reg. No./Substance:
126547-89-5/Intercellular Adhesion Molecule-1; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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