| Responsiveness and habituation of soluble ICAM-1 to acute psychosocial stress in men: determinants and effect of stress-hemoconcentration. | |
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MedLine Citation:
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PMID: 17184150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the psychophysiology of soluble intercellular adhesion molecule-1 (sICAM-1) in 25 apparently healthy middle-aged men who underwent an acute psychosocial stressor three times with one week apart. Measures of the biological stress response were obtained at week one and three. The magnitude of the sICAM-1 stress response showed no habituation between individual visits. At week one, cognitive stress appraisal independently predicted integrated sICAM-1 area under the curve (AUC) between rest, immediately post-stress, and 45 min and 105 min post-stress (beta=0.67, p=0.012, deltaR(2)=0.41). Diastolic blood pressure AUC (beta=-0.45, p=0.048, deltaR(2)=0.21) and heart rate AUC (beta=0.44, p=0.055, deltaR(2)=0.21) were independent predictors of sICAM-1 AUC at week three. Adjustment for hemoconcentration yielded a decrease in sICAM-1 levels from rest to post-stress (p<0.001). Stress responsiveness of plasma sICAM-1 was predicted by stress perception and hemodynamic reactivity and affected by stress-hemoconcentration but unrelated to cortisol reactivity and not readily adapting to repeated stress. |
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Authors:
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R von Känel; D Preckel; B M Kudielka; J E Fischer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-19 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 56 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-01 Completed Date: 2008-02-14 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 627-39 Citation Subset: IM |
Affiliation:
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Department of General Internal Medicine, University Hospital/Inselspital, Bern, Switzerland. roland.vonkaenel@insel.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adaptation, Psychological* Adult Area Under Curve Blood Pressure Case-Control Studies Habituation, Psychophysiologic* Heart Rate Humans Hydrocortisone / blood Intercellular Adhesion Molecule-1 / blood* Male Middle Aged Perception Stress, Psychological / blood*, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
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126547-89-5/Intercellular Adhesion Molecule-1; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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