Document Detail

Responsiveness of the Motor Function Measure in neuromuscular diseases.
MedLine Citation:
PMID:  22705238     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To study the responsiveness (sensitivity to change) of the Motor Function Measure in detecting change in neuromuscular disease patients with the intent of using this Measure in future clinical trials. DESIGN: Prospective cohort observational study. SETTING: Inpatient and outpatient facilities for follow-up and treatment of neuromuscular diseases. PARTICIPANTS: Patients (152) with various neuromuscular diseases aged 6-60 years old. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE(S): We used the Motor function Measure Total score and its four subscores on two measurements grossly one year apart. The physicians and the patients (or proxy) were asked to provide their perceived change in functional status since the first Motor Function Measure. These changes were expressed in three outcomes: deterioration, stability, or improvement RESULTS: The overall 12-month-standardized mean change of the total score mean±SD annual total score change was -2.4±5.5 points (p<0.0001), Duchenne patients presenting the most significant change (-5.8±6.3, p<0.0001). The change in patients reporting deterioration (34%) was significantly larger than that of those reporting stability (47%) or improvement (10%) (-4.4±6.4 vs. -2.0±5.6 and +0.9±4.4 points, respectively; p<0.01). The 12-month-standardized total score changes were significantly greater in physician-rated deteriorated (49%) vs. stable patients (51%) with mean differences in scores -5.3±7.6 and -1.2±5.3 and, respectively (p<0.001). CONCLUSIONS: The Motor Function Measure showed a good responsiveness, especially in Duchenne patients, and agreements with patients' and physician's perceived change. Confirming this responsiveness requires larger age-groups of patients with Duchenne and other neuromuscular diseases as well as disease-specific inter-examination delays.
Carole Vuillerot; Christine Payan; Françoise Girardot; Jacques Fermanian; Jean Iwaz; Carole Bérard; René Ecochard;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-13
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  -     ISSN:  1532-821X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 the American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, L'Escale, Service de Médecine Physique et de Réadaptation Pédiatrique, Bron, F-69500, France.
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