Document Detail


Responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD): results of a randomized trial.
MedLine Citation:
PMID:  23024219     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundHigh fibroblast growth factor-23 (FGF-23) levels are associated with adverse outcomes. We studied the responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD) and healthy control patients.MethodsThirty patients were enrolled: 18 normophosphatemic CKD subjects and 12 healthy controls. The study duration was 21 days with three 7-day dietary interventions; a high phosphate (HP, 2000 mg/day), low phosphate (750 mg/day) and low phosphate plus phosphate binder (aluminum hydroxide, 500 mg thrice daily with meals), with comparable macronutrient content, administered in random sequence. Baseline and weekly fasting morning measurements of FGF-23, serum phosphate (sPO(4)), 1,25-hydroxyvitamin D (1,25 D) and 24-h urinary calcium (uCa) and phosphate (uPO(4)) were collected.ResultsFGF-23 levels were higher in subjects versus controls (72 pg/mL versus 30 pg/mL) at baseline, while sPO(4) remained in the normal range throughout the study. The absolute changes of uPO(4) and uCa for CKD and controls vary according to diet. The absolute changes of FGF-23 and sPO(4) suggest that the effect of the diets might also depend on the CKD status (P-values interaction effect = 0.08 and 0.07, respectively); nonetheless, these changes are evident as a function of dietary interventions, irrespective of CKD status (P-values diet effect = 0.006 and <0.001, respectively).ConclusionsFGF-23 levels appear to be responsive to changes in diet in both CKD patients and controls. Further studies are required to determine whether lowering dietary phosphate and thus FGF-23 levels are of long-term benefit in CKD patients, irrespective of sPO(4) levels.
Authors:
Mhairi Sigrist; Mila Tang; Monica Beaulieu; Gabriella Espino-Hernandez; Lee Er; Ognjenka Djurdjev; Adeera Levin
Related Documents :
25004999 - Hormesis is induced in the red flour beetle tribolium castaneum through ingestion of ch...
25023189 - Do low-calorie drinks 'cheat' the enteral-brain axis?
24406339 - Effect of sitagliptin treatment on metabolism and cardiac function in genetic diabetic ...
15322839 - Octreotide in the treatment of small intestinal dysfunction after a model of jejunoilea...
24498179 - Insights on the host stress, fear and growth responses to the deoxynivalenol feed conta...
23415519 - Hot topic: investigating the risk of violative meat residues in bob veal calves fed col...
17591709 - Effects of pantothenic acid on growth performance and carcass characteristics of growin...
23317399 - The promise of cholesteryl ester transfer protein (cetp) inhibition in the treatment of...
8385089 - Influence of aspergillus oryzae fermentation extract on forage intake, site of digestio...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  -     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A multipronged strategy of an anti-terminator protein to overcome Rho-dependent transcription termin...
Next Document:  Specific impairment of proximal tubular cell proliferation by a monoclonal ? light chain responsible...