Document Detail

Responsiveness of the EuroQol in breast cancer patients undergoing high dose chemotherapy.
MedLine Citation:
PMID:  11789549     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the responsiveness of the EuroQol (EQ-5D) by comparing it with the Functional Living Index-Cancer (FLIC) and a self-reported rating of health-related quality of life (HRQL). METHODS: HRQL was measured four times during the course of high dose chemotherapy (HDC) and bone marrow transplantation in 40 patients with stage II and III breast cancer. Measurements were at baseline (T1), pre-HDC (T2), 3 weeks post-HDC (T3), and 3 months post-HDC (T4). RESULTS: Effect size ranged from 1.16 (T1-T3) to 0.66 (T3-T4) for the EQ-5D and 0.85-0.91 respectively for the FLIC. No significant differences in effect sizes between the EQ-5D and the FLIC were found. Repeated measures ANOVA yielded a significant change for all measures, with HRQL decreasing post-HDC and returning to baseline levels by 3 m post-HDC. EQ-5D dimensions changed significantly over time for mobility, self-care, and usual activities. EQ-5D index scores at T3 had a bimodal distribution. Interpretation of psychological changes was facilitated by an analysis of FLIC items. CONCLUSIONS: The EQ-5D is responsive to the clinically large changes associated with HDC in breast cancer patients. The bimodal distribution of the EQ-5D index has implications for the interpretation of EQ-5D change scores.
B Conner-Spady; C Cumming; J M Nabholtz; P Jacobs; D Stewart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation     Volume:  10     ISSN:  0962-9343     ISO Abbreviation:  Qual Life Res     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-14     Completed Date:  2002-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9210257     Medline TA:  Qual Life Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
Department of Educational Psychology, Faculty of Education, University of Alberta, Edmonton, Canada.
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MeSH Terms
Analysis of Variance
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Bone Marrow Transplantation
Breast Neoplasms / physiopathology*,  psychology,  therapy
Combined Modality Therapy
Dose-Response Relationship, Drug
Health Services Research
Longitudinal Studies
Prospective Studies
Quality of Life*
Self Efficacy
Sickness Impact Profile*

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