| Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics. | |
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MedLine Citation:
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PMID: 20603664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of nucleic acids as therapeutics offers many potential benefits for treating disease. However, for these delicate yet potent biomolecules to be practical in the clinic, carrier vehicles are needed not only to protect the nucleic acids during transport in the body, but also release the biopolymers at the disease site. Polycations can meet the complex needs of nucleic acid delivery as they can condense the polyanionic nucleic acids to form stable polyelectrolyte complexes and, through appropriate design, can release the biotherapeutic at a target site. In this feature article, we review recent advances in the field, and indicate the ways in which future materials of this type might lead to enhanced therapies and treatments for currently untreatable diseases. |
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Authors:
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Mahmoud Soliman; Stephanie Allen; Martyn C Davies; Cameron Alexander |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-07-05 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 46 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 5421-33 Citation Subset: IM |
Affiliation:
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School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Transfer Techniques* / trends Humans Nucleic Acids / administration & dosage* Polyamines / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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BBC5158551//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Polyamines; 0/polycations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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