| Responses of the working rat heart to carbon monoxide. | |
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MedLine Citation:
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PMID: 2813558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of carbon monoxide (CO) were studied in the isolated working rat heart. Hearts removed from male laboratory rats were perfused via the left atrium with Krebs-Henseleit solution (KH) oxygenated with 95% O2-5% CO2 (O2). Heart rate and arterial pressures were measured by a transducer inserted in the aortic outflow line and connected to a data logger. Aortic flow was determined by collecting the effluent from the aortic bubble trap in a graduated cylinder. Coronary flow through the pulmonary cannula was collected and measured in a graduated cylinder. After 30 min, the hearts were challenged with solutions containing either CO (5% CO-90% O2-5% CO2) or N2 (5% N2-90% O2-5% CO2) for 10 min (Challenge I). After recovery in O2, the hearts were challenged with the alternate test solution (Challenge II). CO increased coronary flow (CF) and coronary flow as a percent of cardiac output (CF%) 13 and 16% respectively. N2 had no significant effect on CF or CF%. CO and N2 had no significant effect on heart rate, cardiac output, oxygen consumption or on aortic flow or pressure. These results indicate that vasodilation is the major response of the working heart to CO, and this response is not mediated by simple hypoxia. |
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Authors:
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H Lin; J J McGrath |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 46 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-12-21 Completed Date: 1989-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 81-4 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock 79430. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Carbon Monoxide Poisoning / physiopathology* Carboxyhemoglobin / metabolism Cardiac Output Coronary Circulation Heart / physiopathology* Heart Rate Male Myocardium / metabolism Oxygen Consumption Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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5 T32 HL07289-09/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9061-29-4/Carboxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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