Document Detail


WISE 2005: responses of women to sublingual nitroglycerin before and after 56 days of 6° head-down bed rest.
MedLine Citation:
PMID:  22653986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study tested the hypothesis that cardiovascular effects of sublingual nitroglycerin (NG) would be exaggerated after 56 days of 6° head-down bed rest (HDBR) in women, and that an aerobic and resistive exercise countermeasure (EX, n = 8) would reduce the effect compared with HDBR without exercise (CON, n = 7). Middle cerebral artery maximal blood flow velocity (CBFV), cardiac stroke volume (SV), and superficial femoral artery blood flow (Doppler ultrasound) were recorded at baseline rest and for 5 min following 0.3 mg sublingual NG. Post-HDBR, NG caused greater increases in heart rate (HR) in CON compared with EX (+24.9 ± 7.7 and +18.8 ± 6.6 beats/min, respectively, P < 0.0001). The increase in HR combined with reductions in SV to maintain cardiac output. Systolic, mean, and pulse pressures were reduced 5-10 mmHg by NG, but total peripheral resistance was only slightly reduced at 3 min after NG. Reductions in CBFV of -12.5 ± 3.8 cm/s were seen after NG, but a reduction in the Doppler resistance index suggested dilation of the middle cerebral artery with no differences after HDBR. The femoral artery dilated with NG and blood flow was reduced ∼50% with the appearance of large negative waves suggesting a marked increase in downstream resistance, but there were no effects of HDBR. In general, responses of women to NG were not altered by HDBR; the greater increase in HR in CON but not EX was probably a consequence of cardiovascular deconditioning. These results contrast with the hypothesis and a previous investigation of men after HDBR by revealing no change in cardiovascular responses to exogenous nitric oxide.
Authors:
K A Zuj; H Edgell; J K Shoemaker; M A Custaud; P Arbeille; R L Hughson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-05-31
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2013-01-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-41     Citation Subset:  IM    
Affiliation:
Faculty of Applied Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Sublingual
Adult
Bed Rest*
Blood Flow Velocity / drug effects*
Blood Pressure / drug effects
Cardiovascular Deconditioning / drug effects
Female
Femoral Artery / drug effects,  ultrasonography
Head-Down Tilt / physiology
Heart Rate / drug effects
Humans
Middle Cerebral Artery / drug effects,  ultrasonography
Nitroglycerin / administration & dosage*
Oxygen Consumption / drug effects
Resistance Training
Stroke Volume / drug effects*
Ultrasonography, Doppler
Vascular Resistance / drug effects
Vasodilator Agents / administration & dosage*
Weightlessness Countermeasures
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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