Document Detail

Responses to neither exogenous nor endogenous endothelin-1 are altered in patients with hypercholesterolemia.
MedLine Citation:
PMID:  16177446     Owner:  NLM     Status:  MEDLINE    
There is some controversy regarding whether vascular responses to endothelin are altered in hypercholesterolemia. Studies performed to date have been compromised by the use of endothelin antagonists at inappropriate concentrations. In the current study, we examine the role of endothelin-1 in hypercholesterolemic patients using lower, more selective doses of specific endothelin antagonists. Twenty-two patients with hypercholesterolemia (total plasma cholesterol > 6.0 mmol/l) and 17 healthy controls were recruited. Forearm vascular responses to endothelin-1 (5 pmol/min), the endothelin A antagonist BQ-123 (10 nmol/min), and the endothelin B antagonist BQ-788 (1 nmol/min) were obtained. Endothelin-1 caused a significant vasoconstriction in both hypercholesterolemic and control subjects, an effect that was not significantly different between the two groups (P = 0.784). BQ-123 caused a significant vasodilatation that was not significantly different between the two groups (P = 0.899). Similarly, responses to BQ-788 (P = 0.774) and mean plasma endothelin-1 levels were not different (control vs. hypercholesterolemia, 1.16 +/- 0.18 vs. 1.06 +/- 0.15 fmol/ml; P = 0.64). Responses to neither exogenous nor endogenous endothelin are influenced by plasma cholesterol levels in humans. It is thus unlikely that the endothelin system contributes to early vascular disease pathology in patients with hypercholesterolemia.
Lauren M Boak; Anthony M Dart; Stephen J Duffy; Jaye P F Chin-Dusting
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2005-09-21
Journal Detail:
Title:  Journal of lipid research     Volume:  46     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2667-72     Citation Subset:  IM    
Alfred and Baker Medical Unit, Wynn Domain, Baker Heart Research Institute, Melbourne 3004, Australia.
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MeSH Terms
Blood Pressure
Endothelin-1 / administration & dosage,  antagonists & inhibitors,  blood*,  pharmacology*
Hypercholesterolemia / blood,  drug therapy*,  metabolism*,  physiopathology
Middle Aged
Receptor, Endothelin A / metabolism
Receptor, Endothelin B / metabolism
Regional Blood Flow
Reg. No./Substance:
0/Endothelin-1; 0/Receptor, Endothelin A; 0/Receptor, Endothelin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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