Document Detail


Responses to isoproterenol in a general population sample.
MedLine Citation:
PMID:  736356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The response of forced expiratory flow to inhalation of isoproterenol was evaluated in a general population sample of 1,063 subjects. Percentage changes in the forced expiratory volume in 1 sec and in the maximal flow measured at 50 percent of the initial expired forced vital capacity appeared to be the best indicators of responsiveness to bronchodilator. Subjects with a history of asthma more often showed responsiveness than did the remainder of the population, even when their initial function was within normal limits. Over-all, a high proportion of subjects with abnormalities in baseline forced expiratory volume in 1 sec or maximal flow after exhalation of 50 per cent of the forced vital capacity showed sufficient improvement after bronchodilator to cause their values after isoproterenol to fall within the normal range. The data suggest that responsiveness to bronchodilator aerosol may be a useful guide to the presence of bronchial reactivity in epidemiologic studies of obstructive airway diseases.
Authors:
D B Lorber; W Kaltenborn; B Burrows
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  118     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-03-28     Completed Date:  1979-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  855-61     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / diagnosis,  physiopathology
Female
Forced Expiratory Volume
Humans
Isoproterenol / diagnostic use,  pharmacology*
Lung Diseases, Obstructive / diagnosis,  physiopathology
Male
Maximal Expiratory Flow Rate
Maximal Expiratory Flow-Volume Curves
Middle Aged
Pulmonary Ventilation / drug effects*
Vital Capacity
Chemical
Reg. No./Substance:
7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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