Document Detail

Responses of respiratory drive and breathing pattern to inspiratory loading during nitrous oxide and isoflurane sedation.
MedLine Citation:
PMID:  9809086     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased inspiratory resistance in combination with mild gas narcosis is common during recovery after a general anesthesia, but there are only few previous studies on inspiratory loading during subanesthetic gas narcosis. METHODS: Responses of respiratory drive (central inspiratory activity, P0.1) and ventilatory pattern to an inspiratory threshold load of -6 cm H2O were studied in 16 healthy subjects during mild subanesthetic gas narcosis. One group (n = 9) was exposed to 13, 26 and 39% nitrous oxide (N2O) and air control (Group N). Another group (n = 7) was exposed to 0.1, 0.2 and 0.3% isoflurane and air control (Group I). Measurements were done after 1 min adaptation to the load. RESULTS: Nitrous oxide and isoflurane had no effect on respiratory drive and VT either during unloaded breathing or during inspiratory threshold loading. Across all gas concentrations (including 0% control), inspiratory threshold loading resulted in significant P0.1 increases, amounting to 62% in group N and 38% in group I. At the same time VT decreased by 11 and 12%, respectively. A significantly increased end-expired CO2 and decreased minute volume compared to air control was found during isoflurane inhalation but could be ascribed to normalization of the hyperventilation in the control situation. CONCLUSIONS: It is concluded that the steady-state ventilatory responses to loading, consisting of increased P0.1 and decreased VT, are maintained during inhalation of subanesthetic doses of N2O (0.13-0.38 MAC) and isoflurane (0.09-0.26 MAC).
A Ostlund; D Linnarsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  42     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-14     Completed Date:  1999-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1043-9     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Isoflurane / pharmacology*
Nitrous Oxide / pharmacology*
Respiration / drug effects*
Reg. No./Substance:
0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide; 26675-46-7/Isoflurane

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