Document Detail


Responses of the murine esophageal microcirculation to acute exposure to alkali, acid, or hypochlorite.
MedLine Citation:
PMID:  18779005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: Although ingestion of alkali-based and/or hypochlorite-based household cleaners as well as strong acids remains a major cause of esophageal wall injury, little is known about the mechanisms that underlie the injury response to these toxic agents. This study examined the roles of vascular dysfunction and inflammation to the esophageal injury response to different caustic substances in mice.
METHODS: The esophageal responses to sodium hydroxide (10%, 5%, and 2.5%), potassium hydroxide (10%, 5%, and 2.5%), sodium hypochlorite (5.25%), and hydrochloric acid (10%, pH 2) were evaluated by intravital videomicroscopy and histopathology. Intravital microscopy was used to monitor changes in the diameter of arterioles and venules, the adhesion and movement of leukocytes in venules, and the time of cessation of arteriolar blood flow in mouse esophagus. The esophageal mucosa was exposed to caustic substances for 0 to 60 minutes before evaluation.
RESULTS: The higher concentrations of sodium hydroxide and potassium hydroxide elicited rapid stasis in both arterioles and venules, which was accompanied by arteriolar constriction and thrombosis. An accumulation of adherent leukocytes in venules was not observed with any agent. Histopathological evaluation revealed marked cellular and interstitial edema in the mucosa with alkali, whereas hydrochloric acid and sodium hypochlorite decreased the thickness epithelial layer.
CONCLUSION: These findings suggest that ischemia and thrombosis are dominant processes, whereas inflammation is less important in the pathogenesis of acute corrosive injury to the esophageal mucosa.
Authors:
Mohammad Osman; Janice Russell; Deepty Shukla; Mana Moghadamfalahi; D Neil Granger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  43     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2009-02-11     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1672-8     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103-3932, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caustics / toxicity*
Esophagus / blood supply*,  injuries*,  pathology
Hydrochloric Acid / toxicity*
Hydroxides / toxicity*
Male
Mice
Mice, Inbred C57BL
Microcirculation / drug effects*
Potassium Compounds / toxicity*
Sodium Hydroxide / toxicity*
Sodium Hypochlorite / toxicity*
Grant Support
ID/Acronym/Agency:
DK43875/DK/NIDDK NIH HHS; P01 DK043785-15/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Caustics; 0/Hydroxides; 0/Potassium Compounds; 1310-73-2/Sodium Hydroxide; 7647-01-0/Hydrochloric Acid; 7681-52-9/Sodium Hypochlorite; WZH3C48M4T/potassium hydroxide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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