Document Detail


Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse.
MedLine Citation:
PMID:  18539419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recorded extracellular activity from 402 single units located in the inferior colliculus (IC) of barbiturate-anesthetized albino mice. The stimuli were pure tones at characteristic frequency (CF) with durations of 10, 40 and 100 ms and intensities ranged from 5 to 25 dB above unit's minimum threshold (MT). The tones were presented with different repetition rates (RRs) ranging from 0.2 to 20.0 Hz. At low intensities (5 dB above MT, determined at RR of 0.5 Hz) the great majority of units exhibited a strong decline of their responses when the stimulus RR was increased. About one-half of the units did not respond to 40 ms tones when they were stimulated with the RR of 3.0 Hz. This effect was even more pronounced for 100 ms tones. Generally, the increase in stimulus intensity led to an increase in the high-frequency border of RR. Nevertheless, even at intensities of 20-30 dB above MT, some units showed no response when the RR exceeded 5.0 Hz. In many cases the band-pass or high-pass duration tuning of the single unit was transformed to low-pass or all-pass when the rate was low enough to guarantee the independence of successive presentations of the stimuli. Responses of a very small group of IC units, however, were enhanced when the RR was increased. Our data have shown that the changes in the RR radically modify many features of the neural response (number of spikes, latency, discharge pattern, duration selectivity). We suggest that long-lasting inhibitory processes may be induced by low intensity stimuli in many units of the IC.
Authors:
N G Bibikov; Q C Chen; F J Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-30
Journal Detail:
Title:  Hearing research     Volume:  241     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
Affiliation:
College of Life Sciences, Central China Normal University, Wuhan 430079, PR China.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Anesthesia
Animals
Auditory Perception*
Auditory Threshold
Hypnotics and Sedatives
Inferior Colliculi / cytology,  physiology*
Male
Mice
Neural Inhibition*
Neurons / physiology*
Pentobarbital
Reaction Time
Sound*
Time Factors
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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