Document Detail


Responses of dogs with food allergies to single-ingredient dietary provocation.
MedLine Citation:
PMID:  8755979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To characterize specific food ingredients causing allergic reactions in dogs and to assess cross-reactivity between proteins derived from a single animal source or from different plant products. DESIGN: Prospective study. ANIMALS: 25 dogs with histories and cutaneous signs consistent with food-allergic dermatitis. PROCEDURE: Dogs were fed a food-elimination diet until resolution of clinical signs and then challenged with their original diet. A diagnosis of food allergy was made if there was complete return of pruritus within 14 days of challenge exposure. After diagnosis, dogs were fed the food-elimination diet until signs related to dietary challenge abated. The dogs then were fed beef, chicken, chicken eggs, cows' milk, wheat, soy, and corn in single-ingredient provocation trials for 1 week. Any cutaneous reactions to these food ingredients were recorded by their owners. RESULTS: Beef and soy most often caused adverse cutaneous reactions, although all ingredients induced clinical signs in at least 1 dog. Mean number of allergens per dog was 2.4, with 80% reacting to 1 or 2 proteins and 64% reacting to 2 or more of the proteins tested. A significant difference was found between dogs reacting to beef versus cows' milk and between dogs reacting to soy versus wheat; thus, the hypothesis of cross-reactivity to ingredients derived from a single animal source or to different plant products was not supported. Similar differences between chicken meat and eggs were not identified. CLINICAL IMPLICATIONS: Long-term management of dogs with food allergies is facilitated by identification of the most commonly encountered food allergens. Because cross-reactivity cannot be verified, each protein source should be included separately in food-provocation trials.
Authors:
J G Jeffers; E K Meyer; E J Sosis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  209     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  608-11     Citation Subset:  IM    
Affiliation:
Animal Allergy and Dermatology Clinic, Gaithersburg, MD 20877, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed / adverse effects*
Animals
Cattle
Chickens
Cross Reactions
Dietary Proteins / adverse effects*
Dog Diseases / etiology*
Dogs
Eggs / adverse effects
Female
Food Hypersensitivity / etiology,  veterinary*
Male
Meat / adverse effects
Prospective Studies
Pruritus / etiology,  veterinary*
Soybean Proteins
Soybeans / adverse effects
Triticum / adverse effects
Vegetable Proteins / adverse effects
Zea mays / adverse effects
Chemical
Reg. No./Substance:
0/Dietary Proteins; 0/Soybean Proteins; 0/Vegetable Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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