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Responses of cells to pH changes in the medium.
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MedLine Citation:
PMID:  13993539     Owner:  NLM     Status:  MEDLINE    
Studies were made with time-lapse motion pictures of the reactions of cells in culture to changes in their environment. The concentrations of H(+), HCO(3) (-)and CO(2) in the medium were altered in such a way that each, in turn, could be maintained constant while the others were varied. Observations were made on the shape of the cells, their activity, and their relation to the substratum. Characteristic reversible changes in the cells were observed whenever environmental pH was altered. Elevation of the pH accelerated cell movements and caused contraction of the cytoplasm, while lowering of the pH retarded and eventually stopped all cell activity, causing apparent gelation of the protoplasm. These responses did not occur when HCO(3) (-) and CO(2) were varied without changing the pH. It is suggested that local pH changes in the micro-environment of a cell's surface may be a significant factor in controlling cell behavior in culture and in vivo.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cell biology     Volume:  15     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1962 Nov 
Date Detail:
Created Date:  1963-12-01     Completed Date:  1998-11-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  201-9     Citation Subset:  OM    
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MeSH Terms
Carbon Dioxide*
Cell Biology*
Hydrogen-Ion Concentration*
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1962, by The Rockefeller Institute Press
Print publication date: Day: 1 Month: 11 Year: 1962
Volume: 15 Issue: 2
First Page: 201 Last Page: 209
ID: 2106145
PubMed Id: 13993539

A. Cecil Taylor
From The Rockefeller Institute

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