| Responses of cells to pH changes in the medium. | |
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MedLine Citation:
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PMID: 13993539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were made with time-lapse motion pictures of the reactions of cells in culture to changes in their environment. The concentrations of H(+), HCO(3) (-)and CO(2) in the medium were altered in such a way that each, in turn, could be maintained constant while the others were varied. Observations were made on the shape of the cells, their activity, and their relation to the substratum. Characteristic reversible changes in the cells were observed whenever environmental pH was altered. Elevation of the pH accelerated cell movements and caused contraction of the cytoplasm, while lowering of the pH retarded and eventually stopped all cell activity, causing apparent gelation of the protoplasm. These responses did not occur when HCO(3) (-) and CO(2) were varied without changing the pH. It is suggested that local pH changes in the micro-environment of a cell's surface may be a significant factor in controlling cell behavior in culture and in vivo. |
Authors:
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A C TAYLOR |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of cell biology Volume: 15 ISSN: 0021-9525 ISO Abbreviation: J. Cell Biol. Publication Date: 1962 Nov |
Date Detail:
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Created Date: 1963-12-01 Completed Date: 1998-11-01 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: Not Available |
Other Details:
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Languages: eng Pagination: 201-9 Citation Subset: OM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Bicarbonates* Carbon Dioxide* Cell Biology* Cytoplasm* Hydrogen-Ion Concentration* |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 124-38-9/Carbon Dioxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Cell Biol ISSN: 0021-9525 ISSN: 1540-8140 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © Copyright, 1962, by The Rockefeller Institute Press Print publication date: Day: 1 Month: 11 Year: 1962 Volume: 15 Issue: 2 First Page: 201 Last Page: 209 ID: 2106145 PubMed Id: 13993539 |
| RESPONSES OF CELLS TO pH CHANGES IN THE MEDIUM | |
| A. Cecil Taylor | |
| From The Rockefeller Institute |
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