Document Detail


Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat.
MedLine Citation:
PMID:  10644619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiunit celiac and single-unit cervical recordings of vagal afferents were performed before and during infusions of fatty acids, triglycerides, or saline into either the ileum or jejunum of the rat. In multiunit recordings, lipids increased activity of vagal afferents to a greater extent than saline. The greatest increases in vagal afferent activity resulted from infusions of linoleic acid, conjugated linoleic acid, or oleic acid. The triglycerides, corn oil or Intralipid, were less effective than the fatty acids in affecting vagal afferent activity. Ileal pretreatment with the hydrophobic surfactant Pluronic L-81 significantly attenuated the response of celiac vagal afferents to ileal infusion of linoleic acid. Single-unit recordings of cervical vagal afferents supported the multiunit data in showing lipid-induced increased vagal afferent activity in approximately 50% of ileal units sampled and 100% of a limited number of jejunal units sampled. These data demonstrate that free fatty acids can activate ileal and jejunal vagal afferents in the rat, and this effect can be attenuated by pretreatment with a chylomicron inhibitor. These data are consistent with the view that lipid-induced activation of vagal afferents could be a potential substrate for the inhibitory effects of intestinal lipids on gastrointestinal function, food intake, and body weight gain.
Authors:
A Randich; W J Tyler; J E Cox; S T Meller; G R Kelm; S S Bharaj
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  278     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R34-43     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Alabama at Birmingham, Alabama 35294, USA. arandich@uab.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Celiac Plexus / cytology,  physiology*
Chylomicrons / physiology
Electrophysiology
Ileum / physiology
Intestines / physiology*
Jejunum / physiology
Lipids / administration & dosage*,  pharmacology
Male
Neck / innervation*
Neurons, Afferent / drug effects*
Poloxamer / pharmacology
Rats
Rats, Sprague-Dawley
Vagus Nerve / cytology,  physiology*
Chemical
Reg. No./Substance:
0/Chylomicrons; 0/Lipids; 106392-12-5/Poloxamer

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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