| Responses of the beagle to protracted irradiation. I. Effect of total dose and dose rate. | |
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MedLine Citation:
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PMID: 1947009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of protracted exposure to 60Co gamma rays on survival and tumor induction in the beagle were investigated. Total accumulated doses of 450, 1050, 1500, and 3000 cGy were given at rates of 3.8, 7.5, 12.8, and 26.3 cGy/day. Hazard models were used to identify trends in mortality associated with radiation exposure. The probability of an acute death (related to hematopoietic aplasia) was positively associated with the total dose received and the rate at which the dose was delivered. Once an animal survived the initial hematopoietic effects of radiation exposure, the risk of death from causes other than cancer, while elevated, was far less responsive than the neoplastic end points. No relationship between tumor or chronic nontumor deaths and dose rate could be identified. However, survival curves for tumor mortality did separate into a pattern clearly dependent on the accumulated dose. |
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Authors:
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B A Carnes; T E Fritz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Radiation research Volume: 128 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-11-29 Completed Date: 1991-11-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 125-32 Citation Subset: IM; S |
Affiliation:
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Biological and Medical Research Division, Argonne National Laboratory, Illinois 60439-4833. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Dose-Response Relationship, Radiation Gamma Rays Models, Biological Neoplasms, Radiation-Induced / mortality* Risk Whole-Body Irradiation* |
| Grant Support | |
ID/Acronym/Agency:
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Y01-CP-50503/CP/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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