Document Detail


Responses of autonomic cardiovascular systems induced by hypoxia: rebound phenomenon and species difference.
MedLine Citation:
PMID:  12066581     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rebound tachycardia, transient increase in heart rate (HR) that was observed immediately after the cessation of hypoxia was investigated. Whether the cardiovascular responses induced by hypoxia depend on species difference is also discussed. Wistar rats were chronically instrumented for measurements of arterial blood pressure (ABP), HR and renal sympathetic nerve activity (RSNA), and then subjected to hypocapnic (Hypo), isocapnic (Iso) or hypercapnic (Hyper) hypoxia. Iso did not affect mean ABP (MAP) or HR, whereas Hypo decreased MAP and increased HR, and Hyper increased MAP and decreased HR. RSNA increased in each hypoxia. After the cessation of Iso and Hyper, HR transiently increased and then returned to that of the control. This HR response did not parallel the changes in RSNA, suggesting that "rebound" tachycardia is not due to a sympathetic but rather a parasympathetic mechanism. Although it has been generally believed that cardiovascular responses to systemic hypoxia depend on the species, there was little difference between the results observed in this study and those in previous studies under similar experimental conditions. Accordingly, we suggest that the cardiovascular responses to systemic hypoxia do not depend on species difference but rather on differences in experimental design.
Authors:
Haruhisa Hirakawa; Yoshiaki Hayashida
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of UOEH     Volume:  24     ISSN:  0387-821X     ISO Abbreviation:  J. UOEH     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-17     Completed Date:  2002-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909645     Medline TA:  J UOEH     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  117-29     Citation Subset:  IM    
Affiliation:
Department of Systems Physiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / physiopathology*
Autonomic Nervous System / physiopathology*
Blood Pressure / physiology
Cardiovascular System / physiopathology*
Cats
Dogs
Hearing / physiology
Humans
Male
Rats
Rats, Wistar
Species Specificity

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