| Responses of primate retinal ganglion cells to perimetric stimuli. | |
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MedLine Citation:
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PMID: 20881286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Perimetry is used clinically to assess glaucomatous ganglion cell loss. It has been proposed that frequency-doubling stimuli are better than the conventional size III perimetric stimulus in preferentially stimulating magnocellular (M) versus parvocellular (P) ganglion cells. However, little is known about how primate ganglion cells respond to perimetric stimuli. The authors recorded contrast responses of M and P ganglion cells to size III and frequency-doubling stimuli and compared contrast gain of M and P cells to these stimuli to assess the ability of these stimuli to preferentially stimulate M versus P cells. METHODS: Data were recorded from 69 macaque retinal ganglion cells, by an in vivo preparation, at eccentricities of 5° to 15°. The size III stimulus was a circular luminance increment 26 min arc in diameter, 200 ms in duration. The frequency-doubling stimulus was a sinusoidal grating (0.5 cyc/deg) temporally modulated in counterphase at 13 Hz. A Michaelis-Menten function was fit to each cell's contrast responses to assess contrast gain. RESULTS: For both size III and frequency-doubling stimuli, ganglion cell responses increased linearly at low contrasts, and then the increase slowed at high contrasts (saturation). The mean (± SE) difference in estimated log contrast gain between M and P cells for the size III stimulus was significantly higher than that for the frequency-doubling stimulus (1.24 ± 0.09 vs. 0.89 ± 0.13; P < 0.01). CONCLUSIONS: The size III stimulus was superior to the frequency-doubling stimulus in preferentially stimulating M cells versus P cells. |
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Authors:
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William H Swanson; Hao Sun; Barry B Lee; Dingcai Cao |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-02-09 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-10 Completed Date: 2011-04-01 Revised Date: 2012-03-19 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 764-71 Citation Subset: IM |
Affiliation:
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School of Optometry, Indiana University, Bloomington, Indiana 47405-3680, USA. wilswans@indiana.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Sensitivity / physiology* Macaca fascicularis Photic Stimulation* Retinal Ganglion Cells / physiology*, radiation effects* Visual Field Tests* Visual Fields / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY007716/EY/NEI NIH HHS; EY013112/EY/NEI NIH HHS; EY019651/EY/NEI NIH HHS; R01 EY007716-17/EY/NEI NIH HHS; R01 EY007716-18/EY/NEI NIH HHS; R01 EY007716-19A2/EY/NEI NIH HHS; R01 EY007716-20/EY/NEI NIH HHS; R01 EY007716-21/EY/NEI NIH HHS; R01 EY019651-01A1/EY/NEI NIH HHS |
| Comments/Corrections | |
Comment In:
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Invest Ophthalmol Vis Sci. 2011 May;52(6):3759; author reply 3759-60
[PMID:
21632705
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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