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Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation.
MedLine Citation:
PMID:  16557807     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Lymph nodes, spleens, and Peyer's patches of germ-free mice are relatively inactive. The tissues are small and contain rare, small, indistinct, germinal zones. When exposed to antigenic stimuli (Salmonella paratyphi A and lymphocytic choriomeningitis virus), the tissues become larger and germinal zones appear coincident with antibodies in the blood. The Peyer's patches were activated if antigen was absorbed from the intestinal lumen into the circulation but not if the antigen was administered parenterally. There was no demonstrable immunological response by the germ-free mouse to Streptococcus faecalis.
M Pollard; N Sharon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  2     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1970 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-06-29     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-100     Citation Subset:  -    
Lobund Laboratory, University of Notre Dame, Notre Dame, Indiana 46556.
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