Document Detail

Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise.
MedLine Citation:
PMID:  19589957     Owner:  NLM     Status:  MEDLINE    
The purpose of this investigation was to determine the independent and combined effects of aerobic exercise and omega-3 fatty acid (n-3fa) supplementation on lipid and lipoproteins. Sedentary, normoglycemic, nonsmoking men (n = 11) were assigned to perform rest and exercise before and during n-3fa supplementation. Exercise consisted of 3 consecutive days of treadmill walking at 65% maximum O(2) consumption for 60 min. Supplementation consisted of 42 days of 4.55 g/day of n-3fa. A two-way factorial ANOVA with repeated measures revealed significant reductions in total cholesterol (P = 0.001, -9.2%) and triglyceride (P = 0.007, -32.4%) concentrations postexercise. In addition, exercise increased LDL peak particle size (P = 0.001) from 26.2 to 26.4 nm, but not HDL size. The n-3fa supplementation resulted in a significant shift in the distribution of HDL-cholesterol (HDL-C) carried by HDL(2b+2a) (P = 0.001, 14.2%) and HDL(3a+3b) (P = 0.001, -22.8%), despite no significant changes in lipid and lipoprotein-cholesterol concentrations. The majority of the shift in HDL-C was noted in HDL(2b) (P = 0.001, 20.9%) and HDL(3a) (P < 0.001, -31.0%) particles. There were no combined effects of exercise and n-3fa supplementation on lipids and lipoproteins. Three consecutive days of aerobic exercise reduced triglyceride and total cholesterol concentrations with a concomitant increase in LDL peak particle size. In contrast, n-3fa supplementation shifted HDL-C from HDL(3) particles to HDL(2) particles, despite no significant changes in HDL(2)-C and HDL(3)-C concentrations. Exercise and n-3fa supplementation do not synergistically improve serum lipids and lipoproteins, but rather independently affect the metabolism of lipids and lipoproteins.
Joshua S Wooten; Kyle D Biggerstaff; Vic Ben-Ezra
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Publication Detail:
Type:  Journal Article     Date:  2009-07-09
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  107     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-10-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  794-800     Citation Subset:  IM    
Exercise Physiology Laboratory, Department of Kinesiology, Texas Woman's University, Denton, Texas, USA.
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MeSH Terms
Anaerobic Threshold / physiology
Cholesterol, HDL / metabolism*,  ultrastructure*
Cholesterol, LDL / metabolism*,  ultrastructure*
Dietary Supplements
Energy Intake / physiology
Exercise / physiology*
Fatty Acids, Omega-3 / pharmacology*
Hemoglobins / metabolism
Lipids / blood
Lipoproteins, HDL / metabolism*,  ultrastructure*
Lipoproteins, LDL / metabolism*,  ultrastructure*
Middle Aged
Particle Size
Rest / physiology
Young Adult
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Fatty Acids, Omega-3; 0/Hemoglobins; 0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL

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