| Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. | |
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MedLine Citation:
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PMID: 19589957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this investigation was to determine the independent and combined effects of aerobic exercise and omega-3 fatty acid (n-3fa) supplementation on lipid and lipoproteins. Sedentary, normoglycemic, nonsmoking men (n = 11) were assigned to perform rest and exercise before and during n-3fa supplementation. Exercise consisted of 3 consecutive days of treadmill walking at 65% maximum O(2) consumption for 60 min. Supplementation consisted of 42 days of 4.55 g/day of n-3fa. A two-way factorial ANOVA with repeated measures revealed significant reductions in total cholesterol (P = 0.001, -9.2%) and triglyceride (P = 0.007, -32.4%) concentrations postexercise. In addition, exercise increased LDL peak particle size (P = 0.001) from 26.2 to 26.4 nm, but not HDL size. The n-3fa supplementation resulted in a significant shift in the distribution of HDL-cholesterol (HDL-C) carried by HDL(2b+2a) (P = 0.001, 14.2%) and HDL(3a+3b) (P = 0.001, -22.8%), despite no significant changes in lipid and lipoprotein-cholesterol concentrations. The majority of the shift in HDL-C was noted in HDL(2b) (P = 0.001, 20.9%) and HDL(3a) (P < 0.001, -31.0%) particles. There were no combined effects of exercise and n-3fa supplementation on lipids and lipoproteins. Three consecutive days of aerobic exercise reduced triglyceride and total cholesterol concentrations with a concomitant increase in LDL peak particle size. In contrast, n-3fa supplementation shifted HDL-C from HDL(3) particles to HDL(2) particles, despite no significant changes in HDL(2)-C and HDL(3)-C concentrations. Exercise and n-3fa supplementation do not synergistically improve serum lipids and lipoproteins, but rather independently affect the metabolism of lipids and lipoproteins. |
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Authors:
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Joshua S Wooten; Kyle D Biggerstaff; Vic Ben-Ezra |
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Publication Detail:
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Type: Journal Article Date: 2009-07-09 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 107 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-28 Completed Date: 2009-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 794-800 Citation Subset: IM |
Affiliation:
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Exercise Physiology Laboratory, Department of Kinesiology, Texas Woman's University, Denton, Texas, USA. wooten@bcm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaerobic Threshold / physiology Cholesterol, HDL / metabolism*, ultrastructure* Cholesterol, LDL / metabolism*, ultrastructure* Diet Dietary Supplements Energy Intake / physiology Exercise / physiology* Fatty Acids, Omega-3 / pharmacology* Hemoglobins / metabolism Humans Lipids / blood Lipoproteins, HDL / metabolism*, ultrastructure* Lipoproteins, LDL / metabolism*, ultrastructure* Male Middle Aged Particle Size Rest / physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Fatty Acids, Omega-3; 0/Hemoglobins; 0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL |
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