Document Detail

Responses of cells in the midbrain near-response area in monkeys with strabismus.
MedLine Citation:
PMID:  22562519     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate whether neuronal activity within the supraoculomotor area (SOA-monosynaptically connected to medial rectus motoneurons and encode vergence angle) of strabismic monkeys was correlated with the angle of horizontal misalignment and therefore helps to define the state of strabismus.
METHODS: Single-cell neural activity was recorded from SOA neurons in two monkeys with exotropia as they performed eye movement tasks during monocular viewing.
RESULTS: Horizontal strabismus angle varied depending on eye of fixation (dissociated horizontal deviation) and the activity of SOA cells (n = 35) varied in correlation with the angle of strabismus. Both near-response (cells that showed larger firing rates for smaller angles of exotropia) and far-response (cells that showed lower firing rates for smaller angles of exotropia) cells were identified. SOA cells showed no modulation of activity with changes in conjugate eye position as tested during smooth-pursuit, thereby verifying that the responses were related to binocular misalignment. SOA cell activity was also not correlated with change in horizontal misalignment due to A-patterns of strabismus. Comparison of SOA population activity in strabismic animals and normal monkeys (described in the literature) show that both neural thresholds and neural sensitivities are altered in the strabismic animals compared with the normal animals.
CONCLUSIONS: SOA cell activity is important in determining the state of horizontal strabismus, possibly by altering vergence tone in extraocular muscle. The lack of correlated SOA activity with changes in misalignment due to A/V patterns suggest that circuits mediating horizontal strabismus angle and those that mediate A/V patterns are different.
Vallabh E Das
Related Documents :
7505009 - In vitro cytotoxicities of 1,4-naphthoquinone and hydroxylated 1,4-naphthoquinones to r...
3015389 - Effect of o6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to...
7107409 - In vitro hypoxic cytotoxicity of nitroimidazoles: uptake and cell cycle phase specificity.
20732209 - Cellular methods for identification of neurotoxic chemicals and estimation of neurotoxi...
22475529 - Real time observation and kinetic modeling of the cellular uptake and removal of silico...
18949129 - Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse corti...
1772449 - The effect of nicotine on cell proliferation and synthesis of secreted proteins in balb...
23064689 - Relationship between apoptotic markers in semen from fertile men and demographic, hormo...
22174129 - Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susce...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-22
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  53     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-09-27     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3858-64     Citation Subset:  IM    
College of Optometry, University of Houston, TX 77204, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Accommodation, Ocular / physiology
Disease Models, Animal*
Exotropia / physiopathology*
Eye Movements / physiology
Macaca mulatta
Mesencephalon / physiopathology*
Motor Neurons / physiology*
Oculomotor Muscles / innervation*
Pursuit, Smooth / physiology
Vision, Binocular / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis.
Next Document:  Job demands, job resources, and work engagement of Japanese employees: a prospective cohort study.