| Responses of blood lipids and lipoproteins to extended-release niacin and exercise in sedentary postmenopausal women. | |
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MedLine Citation:
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PMID: 20530245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Niacin and exercise positively alter blood lipids and lipoproteins via different mechanisms. However, the effects of niacin combined with exercise on blood lipid and lipoprotein profiles have not been investigated in sedentary postmenopausal women. The current study examined the responses of blood lipids and lipoproteins to niacin and exercise in 18 sedentary postmenopausal women, who underwent four conditions: no-niacin rest, no-niacin exercise, niacin rest, and niacin exercise. Participants ingested 1,000 mg/day of extended-release niacin for 4 weeks during the niacin condition. As an exercise treatment, participants performed a single bout of exercise on a treadmill at 60% heart rate reserve until 400 kcal were expended. Extended-release niacin without the exercise intervention significantly (p < .001) increased high-density lipoprotein cholesterol and high-density lipoprotein-2 cholesterol by 12.4% and 33.3%, respectively, and decreased the total cholesterol to high-density lipoprotein cholesterol ratio by 14.8%. Thus, 4 weeks of 1,000 mg/day of extended-release niacin can improve the blood lipid and lipoprotein profiles in sedentary postmenopausal women. |
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Authors:
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Yunsuk Koh; Vic Ben-Ezra; Kyle D Biggerstaff; David L Nichols |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2010-06-07 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 65 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 924-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Health and Kinesiology, Lamar University, P. O. Box 10039, Beaumont, TX 77710, USA. ykoh@lamar.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antilipemic Agents
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administration & dosage* Delayed-Action Preparations Exercise* Female Humans Lipids / blood* Lipoproteins / blood* Middle Aged Niacin / administration & dosage* Postmenopause Sedentary Lifestyle |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Delayed-Action Preparations; 0/Lipids; 0/Lipoproteins; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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