Document Detail

Response of urinary lipophilic aldehydes and related carbonyl compounds to factors that stimulate lipid peroxidation in vivo.
MedLine Citation:
PMID:  10984108     Owner:  NLM     Status:  MEDLINE    
Peroxidation of lipids results in the formation of a number of aldehydic and other carbonyl-containing secondary degradation products. The effect of peroxidative stimuli mediated by vitamin E deficiency, a diet high in polyunsaturated fatty acids (containing cod liver oil), and carbon tetrachloride administration on urinary excretion of a number of lipophilic aldehydes and related carbonyl compounds was examined in rats. These secondary lipid peroxidation products were measured as 2,4-dinitrophenylhydrazine derivatives. All three treatments increased urinary excretion of secondary lipid peroxidation products, although the pattern of excretion of these products varied somewhat among the treatments. Significant increases were found in butanal, hexanal, octanal, butan-2-one, pentan-2-one, hex-2-enal, hepta-2,4-dienal, 4-hydroxyhex-2-enal, 4-hydroxyoct-2-enal, 4-hydroxynon-2-enal, and a number of unidentified carbonyl compounds. These results suggest that urinary excretion of these lipophilic secondary lipid peroxidation products is a useful and noninvasive marker of whole-body lipid peroxidation.
A S Csallany; S S Kim; D D Gallaher
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  35     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-11     Completed Date:  2001-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  855-62     Citation Subset:  IM    
Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.
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MeSH Terms
Aldehydes / urine*
Chromatography, High Pressure Liquid
Lipid Peroxidation*
Phenylhydrazines / metabolism*
Rats, Sprague-Dawley
Vitamin E / pharmacology
Reg. No./Substance:
0/Aldehydes; 0/Phenylhydrazines; 119-26-6/2,4-dinitrophenylhydrazine; 1406-18-4/Vitamin E
Erratum In:
Lipids 2001 Jan;36(1):107

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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