Document Detail

Response of type I membranoproliferative glomerulonephritis to pulse methylprednisolone and alternate-day prednisone therapy.
MedLine Citation:
PMID:  7632508     Owner:  NLM     Status:  MEDLINE    
Sixteen children with biopsy-confirmed type I membranoproliferative glomerulonephritis (MPGN) were treated with six alternate-day intravenous pulses of methylprednisolone followed by single-dose alternate-day prednisone for 12-66 months (mean 37 months). The average length of follow-up was 52 months (range 12-127 months). Compared with pretreatment values, the frequency of hematuria (13/16 vs. 8/16, P < 0.05) and the levels of serum albumin (2.66 +/- 0.69 vs. 3.76 +/- 0.39 g/dl, P < 0.001), creatinine clearance (97 +/- 37 vs. 129 +/- 26 ml/min/1.73 m2, P < 0.001), and proteinuria (5.2 +/- 5.1 vs. 1.0 +/- 0.8 g/day, P < 0.001) were significantly improved after 3 months of therapy. Improvement has persisted through the end of the follow-up period. Repeat kidney biopsies showed a significant reduction in acute changes but an increase in chronic changes. Thirteen patients have been off therapy from 1 to 74 months (mean 20.8 months). Nine have a normal urinalysis, creatinine clearance, and protein excretion. The remainder have normal renal function but proteinuria ranging from 3.2 to 4.3 g/day. The data support the evidence of other investigators that corticosteroid therapy is beneficial in type I MPGN and suggest that initiation with pulse methylprednisolone may promote early stabilization of the disease.
J M Bergstein; S P Andreoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  9     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-09-12     Completed Date:  1995-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  268-71     Citation Subset:  IM    
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA.
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MeSH Terms
Child, Preschool
Creatinine / blood
Drug Administration Schedule
Drug Therapy, Combination
Follow-Up Studies
Glomerulonephritis, Membranoproliferative / drug therapy*,  metabolism,  pathology
Infusions, Intravenous
Methylprednisolone / administration & dosage*
Prednisone / administration & dosage*
Proteinuria / drug therapy
Retrospective Studies
Serum Albumin / metabolism
Treatment Outcome
Reg. No./Substance:
0/Serum Albumin; 53-03-2/Prednisone; 60-27-5/Creatinine; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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