| Response of two annular prostheses to functional mitral regurgitation main determinants: an in vitro evaluation. | |
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MedLine Citation:
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PMID: 21042057 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Functional mitral regurgitation (FMR) is usually treated through annuloplasty, i.e., the restriction of the mitral annulus by implanting an undersized prosthetic ring. We conceived a steady-state fluid-dynamic mock simulator that allows for controlling the main mechanic determinants of FMR: transmitral pressure and papillary muscle (PM) apical and lateral dislocation. We used our system to compare the FMR-specific Geoform ring with the general purpose Physio ring in the treatment of FMR. Each ring was implanted on 10 excised fresh porcine valves. Different transmitral pressures (40, 80, 120, 140, and 160 mm Hg) and symmetrical PM apical displacements (2.5-15 mm, step 2.5 mm) were imposed with submillimetric precision. In each configuration, the regurgitant flow through the valve was measured. For PM apical displacement ≥7.5 mm, the regurgitant flow was lower (p < 0.05) with the Geoform ring than with the Physio ring. Differences and their statistical significance increased as PM displacement or transmitral pressure increased. Regression analysis showed that this outcome did not depend on the morphology of the valves. The adopted approach proved itself simple and reliable and allowed to highlight the differences between the two examined annuloplasty devices in countering the two main determinants of FMR: high apical PM dislocation and transvalvular pressure. |
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Authors:
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Emiliano Votta; Riccardo Vismara; Alberto Redaelli; Lorenzo Arcobasso; Francesco Maisano; Ottavio Alfieri; Gianfranco B Fiore |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 56 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 491-6 Citation Subset: IM |
Affiliation:
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Bioengineering Department, Politecnico di Milano, Milano, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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