| Response of tumour cells to hypoxia: role of p53 and NFkB. | |
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MedLine Citation:
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PMID: 9713587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxia is present in several areas of malignant tumours and is thought to result from an inadequate rate of tumour angiogenesis, vascular collapse, or both. The presence and extent of these hypoxic tumour microenvironments have recently been shown to influence tumour progression by regulating both tumour cell survival and the expression of key angiogenic molecules. Recent studies have suggested that mutations in the tumour suppressor gene, p53, may play an important role in regulating the adaptive response of tumour cells to hypoxia by enhancing their survival and release of proangiogenic factors such as vascular endothelial growth factor. It has even been suggested that hypoxia may select for the survival of the more malignant clones harbouring such genetic defects as mutations in p53. Recently, the transcription factor, NFkB, has also been implicated as a novel mediator of the effects of hypoxia and reoxygenation in tumour cells. This article reviews some of the molecular mechanisms subserving the responses of tumour cells to hypoxic stress, particularly the role and relation of NFkB and p53 in regulating this phenomenon. |
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Authors:
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J A Royds; S K Dower; E E Qwarnstrom; C E Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular pathology : MP Volume: 51 ISSN: 1366-8714 ISO Abbreviation: MP, Mol. Pathol. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-08-31 Completed Date: 1998-08-31 Revised Date: 2010-08-25 |
Medline Journal Info:
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Nlm Unique ID: 9706282 Medline TA: Mol Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 55-61 Citation Subset: IM |
Affiliation:
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Institute of Cancer Studies, University of Sheffield Medical School, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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genetics* Genes, p53* Humans Mutation NF-kappa B / genetics* Neoplasms / blood supply, genetics* Neovascularization, Pathologic / genetics |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/NF-kappa B |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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