Document Detail


Response to vaccination against tetanus in chronic haemodialysed patients.
MedLine Citation:
PMID:  1317523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the response to vaccination against tetanus and the changes in the antibody titers 6 months after this vaccination in 66 haemodialysed patients with chronic renal failure. We also investigated the factors that may affect the quality of this immune response. After the booster injection 96.5% of patients had antitetanus antibody titres considered to be protective (0.06 HU/ml). However, the titre of these antibodies rapidly declined and after 6 months, only 62% of the haemodialysed patients had a titre greater than 0.06 HU/ml. Among the different factors considered, only age significantly impaired or reduced the immune response. In addition, the acquisition of protection against tetanus was independent of the response to vaccination against hepatitis B in the same subjects. This study showed the efficacy and safety of vaccination against tetanus in hemodialysed patients, though the antibody titres should be assayed several months after vaccination to confirm the persistence of immunization.
Authors:
A Guerin; Y Buisson; M T Nutini; P Saliou; G London; S Marchais
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  7     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-29     Completed Date:  1992-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
Affiliation:
F.H. Manhès, Hospital Center Fleury Mérogis, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial / biosynthesis*,  blood
Clostridium tetani / immunology
Hepatitis B Antibodies / biosynthesis,  blood
Hepatitis B Vaccines
Humans
Middle Aged
Renal Dialysis*
Tetanus Toxoid / adverse effects,  pharmacology*
Viral Hepatitis Vaccines / pharmacology
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Hepatitis B Antibodies; 0/Hepatitis B Vaccines; 0/Tetanus Toxoid; 0/Viral Hepatitis Vaccines

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