Document Detail


Response to rimiterol and salbutamol aerosols administered by intermittent positive-pressure ventilation.
MedLine Citation:
PMID:  4597119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bronchodilator and cardiac effects produced by aerosols of 0.5% salbutamol and 0.5% and 1% rimiterol administered for three minutes in 40% oxygen by intermittent positive-pressure ventilation (I.P.P.V.) were compared in 15 asthmatic patients. Salbutamol and both the concentrations of rimiterol were equipotent in peak bronchodilator effect, but salbutamol had a significantly longer duration of bronchodilator action. There was significantly less increase in heart rate after rimiterol than after salbutamol. Aerosols of 0.5% rimiterol, 0.5% salbutamol, and saline were administered by I.P.P.V. to 10 normal volunteers. There was no difference between the mean heart rates after 0.5% rimiterol and saline but a highly significant increase in mean heart rate was observed after 0.5% salbutamol. It was concluded that 0.5% rimiterol was an effective short-acting bronchodilator drug with little or no cardiac beta(1)-adrenergic activity when administered for three minutes by I.P.P.V. in 40% oxygen.
Authors:
N J Cooke; J A Kerr; R F Willey; M V Hoare; I W Grant; G K Cromptom
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British medical journal     Volume:  2     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1974 May 
Date Detail:
Created Date:  1974-07-12     Completed Date:  1974-07-12     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  250-2     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerosols
Aged
Albuterol / administration & dosage*,  therapeutic use
Asthma / drug therapy*
Beclomethasone / therapeutic use
Bronchodilator Agents / administration & dosage
Electrocardiography
Female
Heart Rate / drug effects
Humans
Male
Middle Aged
Positive-Pressure Respiration*
Prednisolone / therapeutic use
Spirometry
Sympathomimetics / administration & dosage*,  pharmacology,  therapeutic use
Time Factors
Chemical
Reg. No./Substance:
0/Aerosols; 0/Bronchodilator Agents; 0/Sympathomimetics; 18559-94-9/Albuterol; 4419-39-0/Beclomethasone; 50-24-8/Prednisolone
Comments/Corrections

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