Document Detail

Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome.
MedLine Citation:
PMID:  18329814     Owner:  NLM     Status:  MEDLINE    
Numerous studies have documented the consequences of exposure to anesthesia in models of term and post-term infants, evaluating the incidence of cell loss, physiological alterations and cognitive dysfunction. However, surprisingly few studies have investigated the effect of anesthetic exposure on outcomes in newborn rodents, the developmental equivalent of premature human infants. This is critical given that one out of every eight babies born in the United States is premature, with an increased prevalence of surgical procedures required in these individuals. Also, no studies have investigated if the genetic sex of the individual influences the response to neonatal anesthesia. Using the newborn rat as the developmental equivalent of the premature human, we documented the effect of a single bout of exposure to either the inhalant isoflurane or the injectable barbiturate phenobarbital on hippocampal anatomy, hippocampal dependent behavioral performance and normal developmental endpoints in male and female rats. While both forms of anesthesia led to significant decrements in cognitive abilities, along with a significant reduction in volume and neuron number in the hippocampus in adulthood, the decrements were significantly greater in males than in females. Interestingly, the deleterious effects of anesthesia were manifest on developmental measures including surface righting and forelimb grasp, but were not evident on basic physiological parameters including body weight or suckling. These findings point to the hazardous effects of exposure to anesthesia on the developing CNS and the particular sensitivity of males to deficits.
S Rothstein; T Simkins; J L Nuñez
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Publication Detail:
Type:  Journal Article     Date:  2008-02-05
Journal Detail:
Title:  Neuroscience     Volume:  152     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-08-07     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  959-69     Citation Subset:  IM    
Neuroscience Program and Department of Psychology, Michigan State University, 138 Giltner Hall, East Lansing, MI 48824, USA.
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MeSH Terms
Animals, Newborn / anatomy & histology*,  physiology*
Avoidance Learning / drug effects,  physiology
Behavior, Animal / drug effects,  physiology*
Body Temperature / drug effects,  physiology
Body Weight / drug effects,  physiology
Exploratory Behavior / drug effects
Forelimb / drug effects,  physiology
Hippocampus / cytology,  drug effects,  growth & development,  physiology
Isoflurane / pharmacology
Maze Learning / drug effects
Memory / drug effects,  physiology
Neurons / drug effects,  physiology
Phenobarbital / pharmacology
Psychomotor Performance / drug effects,  physiology
Rats, Sprague-Dawley
Sex Characteristics*
Grant Support
K01 MH068347-04/MH/NIMH NIH HHS
Reg. No./Substance:
26675-46-7/Isoflurane; 50-06-6/Phenobarbital

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