| Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome. | |
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MedLine Citation:
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PMID: 18329814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous studies have documented the consequences of exposure to anesthesia in models of term and post-term infants, evaluating the incidence of cell loss, physiological alterations and cognitive dysfunction. However, surprisingly few studies have investigated the effect of anesthetic exposure on outcomes in newborn rodents, the developmental equivalent of premature human infants. This is critical given that one out of every eight babies born in the United States is premature, with an increased prevalence of surgical procedures required in these individuals. Also, no studies have investigated if the genetic sex of the individual influences the response to neonatal anesthesia. Using the newborn rat as the developmental equivalent of the premature human, we documented the effect of a single bout of exposure to either the inhalant isoflurane or the injectable barbiturate phenobarbital on hippocampal anatomy, hippocampal dependent behavioral performance and normal developmental endpoints in male and female rats. While both forms of anesthesia led to significant decrements in cognitive abilities, along with a significant reduction in volume and neuron number in the hippocampus in adulthood, the decrements were significantly greater in males than in females. Interestingly, the deleterious effects of anesthesia were manifest on developmental measures including surface righting and forelimb grasp, but were not evident on basic physiological parameters including body weight or suckling. These findings point to the hazardous effects of exposure to anesthesia on the developing CNS and the particular sensitivity of males to deficits. |
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Authors:
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S Rothstein; T Simkins; J L Nuñez |
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Publication Detail:
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Type: Journal Article Date: 2008-02-05 |
Journal Detail:
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Title: Neuroscience Volume: 152 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-08-07 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 959-69 Citation Subset: IM |
Affiliation:
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Neuroscience Program and Department of Psychology, Michigan State University, 138 Giltner Hall, East Lansing, MI 48824, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia* Animals Animals, Newborn / anatomy & histology*, physiology* Avoidance Learning / drug effects, physiology Behavior, Animal / drug effects, physiology* Body Temperature / drug effects, physiology Body Weight / drug effects, physiology Exploratory Behavior / drug effects Female Forelimb / drug effects, physiology Hippocampus / cytology, drug effects, growth & development, physiology Isoflurane / pharmacology Male Maze Learning / drug effects Memory / drug effects, physiology Neurons / drug effects, physiology Phenobarbital / pharmacology Psychomotor Performance / drug effects, physiology Rats Rats, Sprague-Dawley Sex Characteristics* |
| Grant Support | |
ID/Acronym/Agency:
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K01 MH068347-04/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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26675-46-7/Isoflurane; 50-06-6/Phenobarbital |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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