Document Detail

Response to methadone maintenance and counseling in antisocial patients with and without major depression.
MedLine Citation:
PMID:  8955683     Owner:  NLM     Status:  MEDLINE    
This study compared the treatment response of four groups of psychiatrically diverse opiate-dependent, methadone maintenance patients receiving drug counseling. The four groups were patients with no other nonsubstance abuse axis I psychiatric diagnoses (OP only; N = 65), patients with lifetime major depression (DEP; N = 60), patients with both antisocial personality disorder and lifetime major depression (APD + DEP; N = 35), and patients with only APD (APD only; N = 24). Patients were assessed at intake, during treatment, and 7 months after treatment admission. No statistically significant differences were found among the groups in treatment retention/attendance. Few significant group differences were revealed during-treatment urine screens, except that barbiturate use was more common for the APD only group. The APD only group also had significantly more positive urine screens for benzodiazepines than the other three groups at 7-month follow-up. All groups reported considerable improvement in problem level at 7 months compared with admission status. The APD only group reported fewer gains in legal and employment problems than the other groups but reported greater improvement in the drug area. Thus, there was some limited support for a prior finding, based on individual psychotherapy, that the treatment response of APD only patients was inferior to that of APD + DEP patients or non-APD patients.
A I Alterman; M J Rutherford; J S Cacciola; J R McKay; G E Woody
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  184     ISSN:  0022-3018     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-01-09     Completed Date:  1997-01-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  AIM; IM    
University of Pennsylvania, Department of Psychiatry, School of Medicine, Philadelphia, Pennsylvania, USA.
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MeSH Terms
Antisocial Personality Disorder / epidemiology,  psychology,  therapy*
Depressive Disorder / complications*,  epidemiology,  therapy
Follow-Up Studies
Methadone / therapeutic use*
Middle Aged
Opioid-Related Disorders / epidemiology,  psychology,  rehabilitation*
Patient Compliance
Psychiatric Status Rating Scales
Substance Abuse Detection
Treatment Outcome
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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