Document Detail

Response to isoproterenol infusion in pediatric patients following atrial repair of transposition of the great arteries.
MedLine Citation:
PMID:  3806933     Owner:  NLM     Status:  MEDLINE    
The postoperative function of the right (systemic) ventricle (SV) was evaluated in eight pediatric patients who had undergone intra-atrial switching for simple transposition of the great arteries (TGA). SV function was evaluated at rest and during isoproterenol (ISP) infusion and compared with left ventricular function in the control group. The control group consisted of five patients including two with postoperative pulmonary stenosis, two with mild pulmonary stenosis and one with postoperative partial anomalous pulmonary venous drainage. SV-graphy was performed at rest. During ISP infusion, the TGA group showed a significant increase in cardiac index (3.50 +/- 0.68 (mean +/- SD) L/min/m2 to 4.94 +/- 1.53 L/min/m2, p less than 0.05) and no significant changes in stroke volume index (SVI). Similar changes were observed in the control group. Resting SV ejection fraction was 0.37 +/- 0.05 in the TGA group. In regard to the relationship between SV end-diastolic pressure and SVI, all but one of the TGA patients showed normal response to the stress. These results indicated that the right ventricle in TGA showed an acceptable response to ISP stress and acted as a systemic ventricle for at least two years after surgery.
H Kato; H Hirose; S Nakao; H Matsuda; Y Kawashima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  50     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-03-18     Completed Date:  1987-03-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  973-9     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Heart Ventricles / drug effects
Isoproterenol / pharmacology*
Myocardial Contraction
Physical Exertion
Postoperative Period
Stroke Volume
Transposition of Great Vessels / surgery*
Ventricular Function*
Reg. No./Substance:

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