Document Detail


Response to isometric exercise in children and young adults with aortic regurgitation.
MedLine Citation:
PMID:  6881028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the hemodynamic response to isometric exercise in 28 children and young adults with aortic regurgitation (AR). Results were compared with those of 18 control subjects without heart disease. Sustained isometric exercise at 33% maximal handgrip capability produced similar increase in heart rate in the two groups. Systolic blood pressure rose to a greater extent in patients with AR than in controls (mean rise 33 mm Hg vs 13 mm Hg). Thirteen of 28 patients with AR had elevated left ventricular end-diastolic diameters at rest. During isometric exercise, left ventricular end-diastolic diameter remained constant in both groups. However, end-systolic diameter increased in patients with AR, resulting in a fall in shortening fraction. The mean left ventricular shortening fraction of the patients with AR fell from 36.0 +/- 1.0% to 32.8 +/- 1.2% (p less than 0.001), but did not change in controls. The fall in shortening fraction was most marked in patients with severe AR. We conclude that patients with AR have an abnormal cardiovascular response to isometric exercise consisting of greater increase in blood pressure and a decrease in left ventricular fractional shortening.
Authors:
C H Gumbiner; H P Gutgesell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  106     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  540-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aortic Valve Insufficiency / physiopathology*
Blood Pressure
Child
Diastole
Echocardiography
Female
Heart Rate
Heart Ventricles / physiopathology
Hemodynamics*
Humans
Isometric Contraction*
Male
Physical Exertion*
Rest
Systole
Grant Support
ID/Acronym/Agency:
HL-07190/HL/NHLBI NIH HHS; RR-00188/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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