| Response to intraarterial oncolytic virotherapy with the Herpes virus NV-1020 evaluated by 18F fluorodeoxyglucose positron emission tomography and computed tomography. | |
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MedLine Citation:
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PMID: 21895536 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Oncolytic virotherapy poses unique challenges to the evaluation of tumor response. We hypothesized that the addition of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to standard computed tomography (CT) evaluation would improve diagnostic and prognostic power of the measurement of tumor response to oncolytic virotherapy. A Phase I/II trial was conducted to investigate treatment of hepatic metastases from colorectal carcinoma using intraarterial administration of the oncolytic herpes virus NV-1020. Both contrast-enhanced CT and FDG-PET were obtained on each patient at each time point. Quantitative FDG-PET and CT responses were correlated with each other and with clinical outcome metrics. A majority of patients showed initial post-viral infusion increases in tumor size (69%) or in standardized uptake value (SUV) (80%) large enough to qualify as progressive disease. Most showed subsequent decreases in tumor size (64%) or SUV (83%) enough to be reclassified as partial response or stable disease. Late PET and CT imaging results correlated well with each other and with clinical outcomes, but results from early in the treatment scheme did not correlate with each other, with later results, or with clinical outcomes. The addition of FDG-PET to the evaluation of tumor response to the oncolytic virus NV-1020 did not provide useful diagnostic or prognostic data. More sophisticated molecular imaging will need to be developed to monitor the effects of this novel class of antineoplastic agents. |
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Authors:
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Daniel Y Sze; Andrei H Iagaru; Sanjiv Gambhir; Hans de Haan; T Reid |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
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Title: Human gene therapy Volume: - ISSN: 1557-7422 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9008950 Medline TA: Hum Gene Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Stanford University Medical Center, Division of Interventional Radiology, H-3646 SUMC, 300 Pasteur Drive, Stanford, California, United States, 94305-5642, 6507255202, 6507250533; dansze@stanford.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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