Document Detail

Response to heart failure therapy: Ventricular volume changes vs. shape changes.
MedLine Citation:
PMID:  22499978     Owner:  NLM     Status:  In-Data-Review    
The prolate ellipsoid left ventricular geometry is crucial for its unique contraction and relaxation patterns. Perturbations in optimal cardiac function preceding overt heart failure ensue when this ellipsoid shape assumes a more spherical configuration; this is the stage when therapy should be intensified. The dynamic shape changes during the cardiac cycle in valvular regurgitation, when ventricular volumes are within the normal range, have proved that shape changes are clearly dissociated from volume changes in the early stages. In advanced heart failure, several therapeutic interventions to decrease the ventricular equator and hence the volume, have been tried with variable success. However, the ventricular shape may still be spherical, leading to suboptimal function. The aim in any therapy for heart failure should therefore be to achieve near normal left ventricular anatomy and physiology, with shape assessment as the surrogate marker of therapeutic success.
Srilakshmi M Adhyapak; V Rao Parachuri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian cardiovascular & thoracic annals     Volume:  20     ISSN:  1816-5370     ISO Abbreviation:  Asian Cardiovasc Thorac Ann     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503417     Medline TA:  Asian Cardiovasc Thorac Ann     Country:  England    
Other Details:
Languages:  eng     Pagination:  210-3     Citation Subset:  IM    
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