Document Detail


Response to exercise in patients with liver cirrhosis: Implications for liver transplantation.
MedLine Citation:
PMID:  23137795     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
End-stage liver cirrhosis is a systemic disease carrying a short-term desperate prognosis without liver transplantation. Given the discrepancy between the growing number of candidates and the limited available liver grafts, the pre-transplantation screening process has become a challenging task. Cardiopulmonary exercise testing, by measuring maximal oxygen consumption at peak exercise, provides a global integrative approach of the health status of an individual. In the setting of liver cirrhosis, decreased oxygen consumption at peak exercise may result from a combination of multiple extra-hepatic complications, including deconditioning, malnutrition-associated muscle weakness, anaemia, cirrhotic cardiomyopathy, and hepato-pulmonary syndrome for instance. In addition, oxygen consumption at peak exercise not only correlated with the severity of the liver disease, but it is also independently associated with survival following liver transplantation. The present article aims to review the numerous determinants of impaired aerobic capacity in patients with severe liver disease, and to discuss how useful is cardiopulmonary exercise testing as a critical tool in the pre-transplantation assessment of these patients.
Authors:
Malcolm Lemyze; Sébastien Dharancy; Benoît Wallaert
Related Documents :
10531145 - Mechanism of overshoot in cardiac function during recovery from submaximal exercise in ...
18196765 - Systolic and diastolic recovery following the harvard step test in adult asian indian men.
11349785 - Functional recovery after extra-ocular muscle deafferentation in the rabbit.
2722325 - Complement and immunoglobulin levels in athletes and sedentary controls.
20156715 - Exhaled nitric oxide - circadian variations in healthy subjects.
16637875 - The response of bone, articular cartilage and tendon to exercise in the horse.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-5
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  -     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Respiratory and Critical Care Medicine, Schaffner Hospital, Lens, France. Electronic address: malcolmlemyze@yahoo.fr.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gender-specific combined effects of smoking and hypertension on cardiovascular disease mortality in ...
Next Document:  The binding of multiple nuclear receptors to a single regulatory region is important for the proper ...