| Response to dietary fat and cholesterol in young adult boars genetically selected for high or low plasma cholesterol. | |
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MedLine Citation:
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PMID: 7592089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-eight young adult boars (age 7 to 8 mo) genetically selected for four generations for high (HG) or low (LG) plasma cholesterol were studied to assess dietary and genetic effects and their interactions on cholesterol metabolism. Boars within a genetic group were paired according to their plasma cholesterol concentration at 8 wk of age and were fed for 15 wk (2.7 kg/d) one of two diets (16.5% fat and 1,156 mg of cholesterol/kg diet, HD; or 3.1% fat and 0 cholesterol diet, LD) in a 2 x 2 factorial arrangement. Plasma total cholesterol (P < .01) and HDL-cholesterol (P < .01) concentrations were higher in boars fed HS (P < .01) and in HG boars (P < .01). There was a trend toward a diet x genotype interaction for plasma HDL-cholesterol (P < .06). Plasma insulin concentration tended to be lower in boars fed HD (P < .09) or HG boars (P < .10). There was a diet x genotype interaction for plasma glucagon (P < .04) concentration and a trend toward an interaction for insulin (P < .07). After 15 wk, all boars were killed by electrocution and exsanguination and measurements were taken. Backfat thickness was greater (P < .01) and carcass length (P < .01) and weights of the four lean cuts (P < .02) were lower in LG than in HG boars. No microscopic atherosclerotic plaques were observed in aorta or coronary arteries. Cholesterol concentration in subcutaneous fat was lower (P < .04) in LG boars, suggesting that cholesterol content of depot fat can be reduced by genetic selection in swine. |
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Authors:
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C D Lu; W G Pond; H J Mersmann; D R Su; L Krook; J J Harris; J W Savell |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of animal science Volume: 73 ISSN: 0021-8812 ISO Abbreviation: J. Anim. Sci. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-11-30 Completed Date: 1995-11-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2043-9 Citation Subset: IM |
Affiliation:
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Dept. of Pediatr., Baylor College of Medicine, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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chemistry Animals Blood Glucose / analysis Brain Chemistry Cholesterol / analysis, blood* Cholesterol, Dietary / pharmacology* Dietary Fats / pharmacology* Genotype Glucagon / blood Insulin / blood Liver / chemistry Male Muscle, Skeletal / chemistry Random Allocation Selection, Genetic* Swine / blood, genetics* Thyroid Hormones / blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, Dietary; 0/Dietary Fats; 0/Thyroid Hormones; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 9007-92-5/Glucagon |
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