| Response to cooling temperature in infants born at an altitude of 4,330 meters. | |
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MedLine Citation:
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PMID: 9847263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolic response to reduction in ambient temperature was studied in healthy, full-term, 1-d-old infants in Lima (50 m altitude, n = 20) and Cerro de Pasco (4,330 m, barometric pressure approximately 450 mm Hg, n = 20), Peru. Oxygen consumption (V O2) and carbon dioxide production (V CO2) were measured with an open-flow system as each infant rested quietly in a cylindrical humicrib, at wall temperatures of 35 degrees C (warm) and 26 degrees C (cool). The infants were exposed for 20 min to both temperatures, with the higher temperature followed by the lower, and oxygen consumption (V O2) and carbon dioxide production (V CO2) were measured over the last 8 min of each exposure. Average birth weight in Cerro de Pasco (2,933 +/- 77 g [mean +/- SE]) was less than in Lima (3,457 +/- 73 g). In warm conditions, infants born at high altitude had slightly yet significantly lower body and skin temperatures than did those born at low altitude, with similar values of V O2 and heart rate (HR). Neither body nor skin temperature changed in either group during cooling. At low altitude, cooling increased V O2 ( approximately 34%), whereas no significant increase occurred in the high-altitude group. A similar response occurred for HR. Among several possibilities, the most likely interpretation of the results would be that of a decreased thermogenic capacity in the high-altitude infants because of the correspondingly lower oxygen availability during gestation. |
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Authors:
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P B Frappell; F León-Velarde; L Aguero; J P Mortola |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 158 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-01-25 Completed Date: 1999-01-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1751-6 Citation Subset: AIM; IM |
Affiliation:
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School of Zoology, La Trobe University, Melbourne, Australia. p.frappell@zoo.latrobe.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Altitude* Analysis of Variance Anoxia / metabolism, physiopathology Biological Availability Birth Weight Body Temperature / physiology* Body Temperature Regulation / physiology Carbon Dioxide / metabolism Cold Temperature* Female Heart Rate / physiology Humans Humidity Infant, Newborn / metabolism, physiology* Male Oxygen Consumption / physiology Peru Skin Temperature / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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