Document Detail


Response to the complete hepatitis B vaccine regimen in infants under 12 months of age: a case series.
MedLine Citation:
PMID:  23279881     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Describing rates of seroconversion and its associated factors in a series of Brazilian infants following the final dose of the vaccine at 6 months of age. METHODS: Peripheral blood samples were collected after the third dose of the vaccine for the detection of anti-hepatitis B surface antibodies among infants of 7-12 months of age. We measured the association between seroconversion and birthweight, gestational age, time since administration of the vaccine in the maternity hospital and whether or not testing for hepatitis B surface antigen had been performed during pregnancy. RESULTS: We examined 40 infants. The mean birthweight was 2787g (standard deviation=853g) and mean gestational age was 37.5 (standard deviation=3,08) weeks. The proportion that seroconverted was non-significantly higher in infants who weighed ≥2000g at birth (96.7%) than in those with birthweights <2000g (80%, p=0,149). There was no difference between the infants who were born at <37 weeks of gestational age and those born at ≥37 weeks (p<0,178) neither between seroconversion and the time of application of the first dose of the vaccine after delivery (p=0,202). CONCLUSION: The proportion of infants who seroconverted was similar to that found in other Brazilian studies. There were no differences in the proportion seroconverting by age at first immunization.
Authors:
Alexandre Lopes Miralha; Adriana Malheiro; Angélica Espinosa Miranda; George Williams Rutherford; Maria das Graças Costa Alecrim
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-29
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  -     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Editora Ltda. All rights reserved.
Affiliation:
Universidade do Estado do Amazonas, Amazonas Foundation of Tropical Medicine, Manaus, AM, Brazil; Department of Maternal and Child Healthcare, Universidade Federal do Amazonas; and the Discipline of Pediatric Healthcare I, Universidade Nilton Lins, Manaus, AM, Brazil. Electronic address: alexmiralha@hotmail.com.
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