Document Detail


Response to azolic antifungal agents for treating feline sporotrichosis.
MedLine Citation:
PMID:  20208075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effectiveness and safety of treatment with ketoconazole and itraconazole were compared in 773 sporotrichosis-infected cats over a four-year period (2002 to 2005). Five hundred and ninety-eight cats received oral ketoconazole and 175 received oral itraconazole. Treatment was successful in 238 (30.8 per cent) cats, of which 171 (28.6 per cent) of 598 received 13.5 to 27.0 mg/kg/day ketoconazole and 67 (38.3 per cent) of 175 received 8.3 to 27.7 mg/kg/day itraconazole. Adverse effects were reported in 306 (39.6 per cent) of the cats, 105 (13.6 per cent) died and 430 (55.6 per cent) dropped out of treatment or were still under treatment at the time of data analysis.
Authors:
S A Pereira; S R L Passos; J N Silva; I D F Gremião; F B Figueiredo; J L Teixeira; P C F Monteiro; T M P Schubach
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Veterinary record     Volume:  166     ISSN:  2042-7670     ISO Abbreviation:  Vet. Rec.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-03-24     Revised Date:  2012-05-10    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  England    
Other Details:
Languages:  eng     Pagination:  290-4     Citation Subset:  IM    
Affiliation:
Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil. sandro.pereira@ipec.fiocruz.br
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antifungal Agents / adverse effects,  therapeutic use*
Appetite / drug effects
Cat Diseases / drug therapy*
Cats
Diarrhea / chemically induced,  veterinary
Female
Itraconazole / adverse effects,  therapeutic use*
Kaplan-Meier Estimate
Ketoconazole / adverse effects,  therapeutic use*
Logistic Models
Male
Sporotrichosis / drug therapy,  veterinary*
Treatment Outcome
Vomiting / chemically induced,  veterinary
Chemical
Reg. No./Substance:
0/Antifungal Agents; 65277-42-1/Ketoconazole; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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